glycosylation

(redirected from O-linked glycosylation)
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Related to O-linked glycosylation: N-linked glycosylation

glycosylation

[glī‚käs·ə′lā·shən]
(biochemistry)
A chemical reaction in which glycosyl groups are added to a protein to produce a glycoprotein.
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References in periodicals archive ?
Glycosylation sites analysis showed that one N-linked glycosylation sites (N20) and eight O-linked glycosylation sites (T22, T24, T25, S33, S38, T41, T46 and S269) were found in the amino acid sequence according to NetNGlyc 1.
Because O-linked glycosylation can occur close to the principal prohormone maturation site in position 74-76 (on the threonyl residue in position 71), the presence of carbohydrate groups affects processing and hormonal maturation (46, 47).
O-linked glycosylation appears to be one source of the heterogeneity (11).
As indicated by the arrow, the trisaccharide form is not detected in homozygous Gc2 individuals, consistent with the Gc2 genotype lacking the preferred site of O-linked glycosylation ([Thr.
Thus, it is possible that the modification preventing antibody binding is O-linked glycosylation.
The effects of O-linked glycosylation on the bioactivity of many signaling molecules, particularly hormones and cytokines, and a relatively small number of enzymes, have been described.