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see skin cancerskin cancer,
malignant tumor of the skin. The most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Rarer forms include mycosis fungoides (a type of lymphoma) and Kaposi's sarcoma.
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melanoblastoma; a malignant tumor that consists of melanin-producing cells.

Factors conducive to the development of melanomas include injury and hormonal stimulation, especially during puberty. Melanomas generally occur on the skin; less often, they appear on the retina, pia mater, nasopharynx, larynx, esophagus, and mucosa of the intestine and other organs. Melanomas usually develop at the site of pigmented or depigmented birthmarks, but they may also appear elsewhere. The process starts with a barely perceptible, painless tumor on the skin, sometimes resembling a wart, which gradually becomes dark brown or black. Occasionally, it ulcerates and bleeds. In case of injury, the tumor may enlarge quickly and become tuberous, dense at the base, and stiffer. The regional lymph nodes enlarge. The initial signs that a melanoma is developing at the site of a birthmark are the birthmark’s enlargement, an intensification or reduction in its pigmentation, and the appearance of a red rim around it. Treatment involves prompt surgical intervention, based on early diagnosis, and the use of radiotherapy and drugs to retard the growth and reproduction of the cells.



A malignant tumor composed of anaplastic melanocytes.
A benign or malignant tumor composed of melanocytes.


Pathol a malignant tumour composed of melanocytes, occurring esp in the skin, often as a result of excessive exposure to sunlight
References in periodicals archive ?
incidence of ocular melanoma at 60 per million as compared to the 153.
Key clinical point: IMCgp100 is clinically active in advanced melanoma, including ocular melanoma and patients refractory to immunotherapy.
Isolated hepatic perfusion with high-dose melphalan results in immediate alterations in tumor gene expression in patients with metastatic ocular melanoma.
Unlike cutaneous melanoma, the incidence of ocular melanoma is not increasing, and the malignancy differs from the cutaneous type in systemic symptoms, metastatic patterns and sensitivity to treatments.
The differential diagnosis of pigmented areas on the conjunctiva includes nevus, racial melanosis, primary acquired melanosis, secondary pigmentary deposition, and ocular melanoma.
Ocular melanoma may develop in any of the uveal structures.
In addition, ganetespib is being evaluated in investigator-sponsored trials including lung, breast, prostate, gastric, pancreatic, and colorectal cancers as well as ocular melanoma, acute myeloid leukemia and multiple myeloma.
M2 PHARMA-December 15, 2017-Aura Biosciences Preclinical Data Support Anti-cancer Activity of AU-011 in Ocular Melanoma
I was diagnosed with ocular melanoma (eye cancer) in 2005 which then spread to my liver three years ago.
In the Collaborative Ocular Melanoma Study (COMS), the 5- and 10-year metastasis rates in choroidal melanoma patients were 25% and 34%, respectively, independently of tumor size.
The company said the physicians in Europe have used CHEMOSAT in both commercial and clinical settings to treat patients for a wide variety of cancers in the liver, ocular melanoma liver metastases, hepatocellular carcinoma and intrahepatic cholangiocarcinoma, liver metastases from colorectal cancer, breast cancer and others.
Writing in a comment piece in the New York Times earlier this year, Dr Sacks describes his life-changing diagnosis of ocular melanoma nine years ago.