Laurent et al  was the first to show the promising biological properties of Biodentine on human fibroblast cultures and reported that angiogenesis, recruitment of progenitor cell by inducing odontoblasts
differentiation, and cell differentiation generates deposition of a reactionary dentine as well as dense dentine bridge.
Autoradiographic analysis of odontoblast
replacement following pulp exposure in primate teeth.
mild, moderate, or severe) and type of inflammatory infiltrate (polymorphonuclear [PMN] or mononuclear [MN]), organization of the odontoblast
layer, blood vessel condition, and presence of abscesses or necrosis (Six, Decup, Lasfargues, Salih, & Goldberg, 2002; Vier-Pelisser, Figueiredo, Cherubini, Braga Filho, & Figueiredo, 2007; Parolia et al.
BMP-2 promotes odontoblast
differentiation and mineral deposition.
They have the capability to differentiate into osteoblasts, odontoblasts
, endothelial cells, adipocytes, and neural cells (10-13).
As observed in humans, the dentin is produced by odontoblasts
(Figure 2E) and the thickness is enhanced at the incisal region.
This suggests that biglycan was involved in odontoblast
differentiation, (16) but that its expression decreases in mature odontoblasts
Inadequate amounts of vitamin C results in changes in the ameloblasts and odontoblasts
; ameloblasts and odontoblast
atrophy, and there is a decrease in their orderly polar arrangement.
Bmp4 is important during the bud-cap stage transition, as it activates Msx1 and Msx2 in the mesenchyme and is necessary for molar development and odontoblast
differentiation [Nie et al.
5] who showed that GC Fuji IX GP fast was the least cytotoxic experimental material evaluated in their study on an odontoblast
cell line (MDPC-23).
Activation of human dental pulp progenitor/stem cells in response to odontoblast
This gene controls osteoblastic differentiation, appropriate osteogenesis and odontogenesis via parcitipation in odontoblast
differentiation, enamel orgen formation and dental lamina proliferation.