oligonucleotide

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Oligonucleotide

A deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequence composed of two or more covalently linked nucleotides. Oligonucleotides are classified as deoxyribooligonucleotides or ribooligonucleotides. Fragments containing up to 50 nucleotides are generally termed oligonucleotides, and longer fragments are called polynucleotides. See Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA)

A deoxyribooligonucleotide consists of a 5-carbon sugar called deoxyribose joined covalently to phosphate at the 5 and 3 carbons of this sugar to form an alternating, unbranched polymer. A ribooligonucleotide consists of a similar repeating structure where the 5-carbon sugar is ribose. Chemically synthesized oligonucleotides of predetermined sequence have proven to be very useful for studying a large number of biochemical processes. In the 1960s, these compounds were used to decipher the genetic code. Later, chemically prepared deoxyoligonucleotides were joined to form genes for transfer RNAs. Gene synthesis from synthetic deoxyoligonucleotides is now routinely used to prepare genes and modified genes for proteins having potential clinical applications. Oligonucleotides have also been used to diagnose genetic disorders and bacterial or viral infections. See Gene, Genetic code, Genetic engineering, Nucleic acid

oligonucleotide

[‚äl·ə·gō′nü·klē·ə‚tīd]
(biochemistry)
A polynucleotide of low molecular weight, consisting of less than 20 nucleotide polymers.
References in periodicals archive ?
CAB Biotin Palmitoyl Pentapeptide-18 (Prevent Hair Loss and Promote Hair Growth) This novel formulation, comprised of CAB Oligo peptides combined with important botanical extracts, supports cell stimulation and metabolism, resulting in a revolutionary product that helps to stimulate hair growth, strength, and prevent hair loss.
It also observable that, among 36 cluster 10 clusters having 1 spacer result which means they are also showing the resulting oligo analysis and showing best suited occurrence significance while remaining 28 clusters having the spacers lies between 2 to 18 that represent the variation among dyad pattern binding sites.
The oligo RNA to be marketed is produced by the novel synthesis method (CEM method) inimitably developed by Nippon Shinyaku.
The Agilent Magnaporthe grisea Oligo Microarray Kit (G4137A) has a novel design that includes, on one microarray, genetic probes from two genomes: rice blast (Magnaporthe grisea), and rice.
Commenting on the therapeutic potential of CpG oligo activated dendritic cells, Dr.
Agilent is excited to be the only company to offer an oligo FISH platform and other molecular analysis products, including SurePrint CGH+SNP microarrays, and HaloPlex and SureSelect next-gen sequencing products, delivering a full set of solutions for cytogenetic research needs.
Designed for maximum flexibility, two NEBNext Oligo Modules are now available: the NEBNext Multiplex Oligos Module includes the adaptor and 12 barcode PCR primers; the NEBNext Singleplex Oligos Module includes the adaptor and primers for singleplex library preparation, and is also compatible with custom barcode PCR primers.
An oligo ester derived from sebacic acid and hydrogenated castor oil, Crodabond CSA adheres to the lifted cuticles, cementing them together and smoothing the hair fiber.
Degussa stated that because Proligo ranks sixth in the oligo market and does have the opportunity to achieve a leading position, and the market is facing consolidation, it decided to sell the business.
The programs available on this page include PCR Oligo Calculator, which lets researchers design batch polymerase chain reaction primers for amplifying the open reading frames for a given set of genes, and Batch Gene Retriever, which allows downloads of full-length sequence information from National Center for Biotechnology Information databases in batch mode.
By nestling into the groove near the disease-causing genes, the added strand -- called an oligo -- prevents those genes from passing their faulty messages to awaiting mRNA couriers.
Avecia maintains the world's largest library of oligo process and manufacturing data at scale, drawing from nearly 20 years of experience.