oligonucleotide

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Oligonucleotide

A deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequence composed of two or more covalently linked nucleotides. Oligonucleotides are classified as deoxyribooligonucleotides or ribooligonucleotides. Fragments containing up to 50 nucleotides are generally termed oligonucleotides, and longer fragments are called polynucleotides. See Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA)

A deoxyribooligonucleotide consists of a 5-carbon sugar called deoxyribose joined covalently to phosphate at the 5 and 3 carbons of this sugar to form an alternating, unbranched polymer. A ribooligonucleotide consists of a similar repeating structure where the 5-carbon sugar is ribose. Chemically synthesized oligonucleotides of predetermined sequence have proven to be very useful for studying a large number of biochemical processes. In the 1960s, these compounds were used to decipher the genetic code. Later, chemically prepared deoxyoligonucleotides were joined to form genes for transfer RNAs. Gene synthesis from synthetic deoxyoligonucleotides is now routinely used to prepare genes and modified genes for proteins having potential clinical applications. Oligonucleotides have also been used to diagnose genetic disorders and bacterial or viral infections. See Gene, Genetic code, Genetic engineering, Nucleic acid

oligonucleotide

[‚äl·ə·gō′nü·klē·ə‚tīd]
(biochemistry)
A polynucleotide of low molecular weight, consisting of less than 20 nucleotide polymers.
References in periodicals archive ?
This can occur in many ways: barcodes that contain overlapping sequence; inadvertently attaching the wrong barcode to a sample; contamination between wells that mixes two barcodes into one sample; or barcodes with such similar sequences that a small error in oligo production makes two or more appear the same.
Some clusters were found to have similar conserved patterns for oligo as well as dyad analysis indicating that these clusters may have the same regulatory elements.
Using this new technology, Nippon Shinyaku can synthesize and provide highly pure and longer oligo RNA efficiently than that made through conventional methods.
0 Oligo Microarray Kit (G4136A), updated to include broader genome coverage.
Agilent is excited to be the only company to offer an oligo FISH platform and other molecular analysis products, including SurePrint CGH+SNP microarrays, and HaloPlex and SureSelect next-gen sequencing products, delivering a full set of solutions for cytogenetic research needs.
He was in charge of launching Oligo Medic's JointRep product throughout Latin America.
The oligo market has changed in the last year as QIAGEN sold its Operon operation (see IBO 6/ 30/04) and Invitrogen partnered with Illumina (see IBO 12/ 31/04).
Commenting on the therapeutic potential of CpG oligo activated dendritic cells, Dr.
By nestling into the groove near the disease-causing genes, the added strand -- called an oligo -- prevents those genes from passing their faulty messages to awaiting mRNA couriers.
Avecia maintains the world's largest library of oligo process and manufacturing data at scale, drawing from nearly 20 years of experience.
Operon will consist of QIAGEN's former custom and modified oligo businesses, shelf products (Array Ready Oligo Sets) and antibody and peptide business, and includes the transfer of QIAGEN Sciences KK (formerly Sawady) QIAGEN Operon GmbH (Cologne) and QIAGEN Operon's Alameda, California and Germantown, Maryland operations QIAGEN noted that the Operon business is different due to its mostly nonproprietary products, custom-made products, fast turn around times and low competitive barriers QIAGEN states that Operon is the number two competitor in the oligo market in the US, Europe and Japan.