Oligonucleotides


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Oligonucleotides

 

natural or synthetic oligomeric compounds composed of a few nucleotide (mononucleotide) radicals connected by a phosphodiester bond. Oligonucleotides are formed during partial chemical or enzymatic hydrolysis of nucleic acids (polynucleotides). The chemical synthesis of oligonucleotides with a given sequence of bases is an important intermediate stage in the synthetic preparation of biologically active polynucleotides.

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M2 EQUITYBITES-November 8, 2017-Nitto Avecia successfully completes multiple oligonucleotide manufacturing synthesis runs at 1.
Considering the potential of oligonucleotides (therapeutic oligonucleotides) in the treatment of chronic diseases, the oligonucleotide synthesis market is expected to flourish in the coming years, provided these drugs get rapid market approvals.
Contract notice: Supply, delivery and installation of an oligonucleotide synthesizer, designed to be incorporated in the synthesis of oligonucleotide purification platform and bioimaging of the institute of the university of bordeaux.
Marina Biotech and Girindus Group have entered into a strategic alliance under which Girindus will have exclusive rights to develop, supply and commercialize certain oligonucleotide constructs using Marina's Conformationally Restricted Nucleotide (CRN) chemistry.
Oligonucleotides show great potential as diagnostic and therapeutic agents for a wide range of human diseases, including cancer, cardiovascular diseases, diabetes, viral infection, and many degenerative disorders.
While traditional methods require eight steps and can take two hours, the Clarity OTX extraction kits isolate oligonucleotide therapeutics and their metabolites in 15 minutes.
Experiments are underway to narrow the 200-bp region of binding by using small overlapping oligonucleotides from the region and to test binding with nuclear extracts from non-hematopoietic cell lines.
0, 10 mmol/L magnesium chloride, 40 pmol of detection oligonucleotides, 40 pmol of PDGF-BB, and typically, 350 mL/L formamide by volume.
The PCR fragment corresponded to the product of amplification between the oligonucleotides ropB1UP (5'ggccgtctgaaCTGTCCGAAGCCCAACAAAAC- TCTTGG3") and rpoBR1.
Dalton Pharma Services, a privately owned Canadian pharmaceutical services provider to leading pharmaceutical companies, recently announced the completion of its state-of-art Oligonucleotide Production Suite.
Avecia is the world leader in the development and manufacture of cGMP oligonucleotides for therapeutic applications.
Montreal, Canada) has patented a method for using antisense oligonucleotides directed against specific nucleic acid sequences coding for receptors, alone or in combination, in order to inhibit the inflammatory reaction that is present in asthma, atopy or hypereosinophilia and to inhibit neoplastic cell proliferation.