Oligonucleotides


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Oligonucleotides

 

natural or synthetic oligomeric compounds composed of a few nucleotide (mononucleotide) radicals connected by a phosphodiester bond. Oligonucleotides are formed during partial chemical or enzymatic hydrolysis of nucleic acids (polynucleotides). The chemical synthesis of oligonucleotides with a given sequence of bases is an important intermediate stage in the synthetic preparation of biologically active polynucleotides.

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Experiments are underway to narrow the 200-bp region of binding by using small overlapping oligonucleotides from the region and to test binding with nuclear extracts from non-hematopoietic cell lines.
Oligonucleotide Therapeutics Society Meeting (1st: 2005: New York, N.
0, 10 mmol/L magnesium chloride, 40 pmol of detection oligonucleotides, 40 pmol of PDGF-BB, and typically, 350 mL/L formamide by volume.
The PCR fragment corresponded to the product of amplification between the oligonucleotides ropB1UP (5'ggccgtctgaaCTGTCCGAAGCCCAACAAAAC- TCTTGG3") and rpoBR1.
Dalton Pharma Services, a privately owned Canadian pharmaceutical services provider to leading pharmaceutical companies, recently announced the completion of its state-of-art Oligonucleotide Production Suite.
Avecia is the world leader in the development and manufacture of cGMP oligonucleotides for therapeutic applications.
This cytoplasmic mRNA is in the "sense" orientation, and so translation can be prevented by complementary base-pair binding of "antisense" oligonucleotides as short as 18 bases long (1), either by steric blocking of translation or by destruction of the bound mRNA via RNase-H (Figure 1).
The announcement was in sharp contrast to Invitrogen's steady growth over the last few years In the conference call, Invitrogen said it expects sales to be off by $7 million for its oligonucleotide and service businesses in the first quarter and molecular biology sales to be off $16 million in the first quarter.
The group showed that unpurified commercially available oligonucleotides could be used, greatly simplifying the site-directed mutation process.
The probes, known as oligonucleotides, are short man-made pieces of DNA-like molecules.
That mechanism probably holds less appeal for scientists and investors, who are looking for a smart drug that does one thing and one thing only It may be that many different oligonucleotides act in the same way.
Nasdaq: IDRA) today announced the issuance of patents covering compositions and methods of using its synthetic immune modulatory oligonucleotides targeted to Toll-like receptors (TLRs).