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A deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequence composed of two or more covalently linked nucleotides. Oligonucleotides are classified as deoxyribooligonucleotides or ribooligonucleotides. Fragments containing up to 50 nucleotides are generally termed oligonucleotides, and longer fragments are called polynucleotides. See Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA)

A deoxyribooligonucleotide consists of a 5-carbon sugar called deoxyribose joined covalently to phosphate at the 5 and 3 carbons of this sugar to form an alternating, unbranched polymer. A ribooligonucleotide consists of a similar repeating structure where the 5-carbon sugar is ribose. Chemically synthesized oligonucleotides of predetermined sequence have proven to be very useful for studying a large number of biochemical processes. In the 1960s, these compounds were used to decipher the genetic code. Later, chemically prepared deoxyoligonucleotides were joined to form genes for transfer RNAs. Gene synthesis from synthetic deoxyoligonucleotides is now routinely used to prepare genes and modified genes for proteins having potential clinical applications. Oligonucleotides have also been used to diagnose genetic disorders and bacterial or viral infections. See Gene, Genetic code, Genetic engineering, Nucleic acid

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.


A polynucleotide of low molecular weight, consisting of less than 20 nucleotide polymers.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Synthesized oligos dominated the oligonucleotide synthesis market, by product, in 2018
It produces oligonucleotide ('oligo') active pharmaceutical ingredients, which hold the potential to treat cancer, rare and infectious diseases, cardiovascular indications, and other disorders.
The oligos and probes designed in the study complemented all types of pathogenic fungi without discrimination of genera of species in results.
Indeed, the quality required for oligos has never been higher.
Surprisingly, only one out of the used oligo sets, including the most internal ones, gave rise to amplicons (see Figure S2 and Table S1).
AUMmirblocker self-transfecting oligos serve as competitive blockers/decoys against miRNAs to inhibit their binding with target mRNA.
"This patent covers both the in vivo and ex vivo activation of dendritic cells using our CpG oligos," said Robert L.
The industrial experience held by Genset Oligos will make Proligo a fully integrated supplier of nucleic acid specialties (genomics and genetic medicine).
patents; he founded Oregon's pioneering biotech company AVI Biopharma in 1980; his morphoilno oligos -- synthetic compounds that he invented and patented -- are used by researchers worldwide and might eventually help cure cancer, viral and autoimmune diseases.
Two types of glial cells are familiar to people who read up on MS--the astrocytes, which normally support the nerve-cell fibers or axons, and the oligodendrocytes, oligos for short, which produce that essential myelin.