oncogene

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oncogene

any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer

oncogene

[′äŋ·kō‚jēn]
(genetics)
A gene whose mutation can lead to cancer in experimental animals and humans.
References in periodicals archive ?
We see this type of collaborative effort as a model for the future development of therapeutic antibodies based on new oncogenes discovered by Tularik.
The researchers initially found notonly the oncogene but in many cases extra copies of it in 19 of 103 fresh tumor samples.
17 September 2014 - South Korean PNA (Peptide Nucleic Acid) oligomer manufacturer Panagene Inc said yesterday it had developed four commercial ctDNA test kits able to identify mutated oncogene through blood test alone.
Subsequent work revealed that let-7 regulates a number of other oncogenes, including CCND2 (cyclin D2), CDK6 (cyclin-dependent kinase 6), CDC25 [cell division cycle 25 homolog C (S.
Jackson, has identified a new oncogene, which is a gene that contributes to the development of cancer, named FAM83B.
Most approaches to produce human iPS cells use retroviruses to activate and/ or express multiple key genes, including an oncogene that is associated with production of cancer cells.
By examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes handle cellular stress, scientists from the Institute for Advanced Studies in New Jersey argue that each of these opposing systems could be potent drug targets in the effort to stop cancer.
However, proto-oncogenes can promote cancer development only if they acquire new properties as a result of mutations at which point they are known as oncogenes.
Oncogenes harbor gain-of-function somatic mutations that are sufficient to transform normal cells into malignant ones.
Researchers also discovered a surprisingly large number of instances in which the same set of mutations occurred within tumor cells, suggesting that oncogenes often worked in partnership.
Tokyo, Japan, Feb 13, 2006 - (JCN) - The Tohoku University Graduate School of Medicine has discovered that two different oncogenes KRAS and BRAF play a key role in the occurrence of cardiofaciocutaneous (CFC) syndrome.
Bishop and Varmus a few years earlier had cloned the first cellular oncogenes.