vincristine

(redirected from Oncovin)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to Oncovin: procarbazine, prednisone, vincristine

vincristine

[vin′kri‚stēn]
(pharmacology)
C46H56O10N4 An alkaloid extracted from the periwinkle plant (Vinca rosea) and used, as the sulfate salt, as an antineoplastic drug. Also known as leurocristine.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The mechlorethamine, oncovin, procarbazine, prednisone (MOPP) therapy, used in lymphoma treatment, causes amenorrhea in up to 80% of female patients and acute ovarian failure in 39-46% of young adults [7].
For example, administration of a high dose of selenium (0.2 mg per kg of body weight per day for 5 days, given on days 3-7 of chemotherapy) significantly reduced the proportion of patients with non-Hodgkin's lymphoma being treated with cyclophosphamide, doxorubicin, Oncovin, and prednisone who developed an infection after chemotherapy (20% vs.
MOPP - mechlorethamine + oncovin (vincristine) + procarbazine + prednisone
CHOP - cyclophosphamide (cytoxan) + adriamycin (doxorubicin) + oncovin (vincristine) + prednisone
COMP - cyclophosphamide (cytoxan) + oncovin (vincristine) + methotrexate + prednisone
When treated with rituximab, cyclophosphamide, doxorubicin (adriamycin), Oncovin (vincristine), and prednisone (R-CHOP), MYC-translocated DLBCL was associated with inferior progression-free survival (31% versus 66%) and overall survival (33% versus 72%), compared with all other DLBCLs.
The patient received 2 cycles of cyclophosphamide, Adriamycin (hydroxydoxorubicin), Oncovin (vincristine), and prednisone-rituximab (R-CHOP) with no response.
(4,7,8,10) Consensus guidelines recommend that these lymphomas be treated similarly to a systemic diffuse large B-cell lymphoma with an anthracycline-containing chemotherapeutic regimen, such as rituximab, cyclophosphamide, doxorubicin (adriamycin), oncovin (vincristine), and prednisone (R-CHOP), and possibly including involved field radiation therapy.
Cyclophosphamide, Adriamycin, Oncovin, and prednisone (CHOP) and CHOP-like chemotherapy have achieved positive objective responses; however, anthracycline-based chemotherapy has been associated with superior remission and overall survival rates.
Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine.
Because of her symptoms of fever and night sweats and the histologic findings demonstrating HD, lymphocyte-depleted type, the patient received cyclophosphamide, doxorubicin, vincristine (Oncovin), and prednisone chemotherapy for the next 6 months without any serious adverse effects.
Combined chemotherapy consisting of 6 courses of standard CHOP (cyclophosphamide, hydroxydaunomycin, Oncovin [vincristine], and prednisone) and additional 25 sessions of 45 Gy of fractionated radiation treatment were administered.