The mechlorethamine, oncovin
, procarbazine, prednisone (MOPP) therapy, used in lymphoma treatment, causes amenorrhea in up to 80% of female patients and acute ovarian failure in 39-46% of young adults .
For example, administration of a high dose of selenium (0.2 mg per kg of body weight per day for 5 days, given on days 3-7 of chemotherapy) significantly reduced the proportion of patients with non-Hodgkin's lymphoma being treated with cyclophosphamide, doxorubicin, Oncovin
, and prednisone who developed an infection after chemotherapy (20% vs.
MOPP - mechlorethamine + oncovin (vincristine) + procarbazine + prednisone
CHOP - cyclophosphamide (cytoxan) + adriamycin (doxorubicin) + oncovin (vincristine) + prednisone
COMP - cyclophosphamide (cytoxan) + oncovin (vincristine) + methotrexate + prednisone
When treated with rituximab, cyclophosphamide, doxorubicin (adriamycin), Oncovin
(vincristine), and prednisone (R-CHOP), MYC-translocated DLBCL was associated with inferior progression-free survival (31% versus 66%) and overall survival (33% versus 72%), compared with all other DLBCLs.
The patient received 2 cycles of cyclophosphamide, Adriamycin (hydroxydoxorubicin), Oncovin
(vincristine), and prednisone-rituximab (R-CHOP) with no response.
(4,7,8,10) Consensus guidelines recommend that these lymphomas be treated similarly to a systemic diffuse large B-cell lymphoma with an anthracycline-containing chemotherapeutic regimen, such as rituximab, cyclophosphamide, doxorubicin (adriamycin), oncovin
(vincristine), and prednisone (R-CHOP), and possibly including involved field radiation therapy.
Cyclophosphamide, Adriamycin, Oncovin
, and prednisone (CHOP) and CHOP-like chemotherapy have achieved positive objective responses; however, anthracycline-based chemotherapy has been associated with superior remission and overall survival rates.
Treatment for stage IVB Hodgkin lymphoma was begun, consisting of cytoxan, oncovin
, prednisone, and procarbazine alternating with adriamycin, bleomycin, and vinblastine.
Because of her symptoms of fever and night sweats and the histologic findings demonstrating HD, lymphocyte-depleted type, the patient received cyclophosphamide, doxorubicin, vincristine (Oncovin
), and prednisone chemotherapy for the next 6 months without any serious adverse effects.
Combined chemotherapy consisting of 6 courses of standard CHOP (cyclophosphamide, hydroxydaunomycin, Oncovin
[vincristine], and prednisone) and additional 25 sessions of 45 Gy of fractionated radiation treatment were administered.