anticoagulant

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Related to Oral anticoagulants: Rivaroxaban, warfarin

anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Beyond clinical trials, there is a wealth of available health insurance data that provides an excellent opportunity to grow our knowledge of oral anticoagulant use and outcomes for patients," said lead investigator John Seeger, PharmD, DrPH, Department of Medicine, Brigham and Women's Hospital, a teaching-affiliate of Harvard Medical School.
Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: A systematic review.
Another worrying finding was that oral anticoagulants were underprescribed in elderly patients, with aspirin alone more commonly prescribed.
When changing to one of the novel oral anticoagulants, warfarin should be withdrawn and the INR monitored daily.
While on oral anticoagulant therapy, 31 patients experienced hemorrhages.
DTIs prolong clotting times in PT assays and therefore interfere with oral anticoagulants (15-18).
The AvoSure PT-Pro provides efficient monitoring of patients on oral anticoagulant therapy to the doctor's office or home healthcare nurse where high-quality prothrombin time test results are needed in a timely manner.
According to surveyed Brazilian cardiologists, new branded oral anticoagulants, such as Boehringer-Ingelheim's Pradaxa (dabigatran) and Bayer/Janssen's Xarelto (rivaroxaban), will capture 79 percent of Brazil's atrial fibrillation drug market in 2016, owing to their relatively high prices and superior clinical profiles over warfarin (Bristol-Myers Squibb's Coumadin, generics) and aspirin.
Crivera "are not definitive on their own, but they add to a growing body of data that indicate that all the new oral anticoagulants are cost effective," said Dr.
X-VeRT, the first prospective trial of a novel oral anticoagulant, showed that compared with the use of VKA, rivaroxaban was associated with a numerical reduction in the risk of cardiovascular events of 50 per cent in the composite primary efficacy outcome of stroke, transient ischemic attack, peripheral embolism, myocardial infarction and cardiovascular death, with a numerically lower risk of major bleeding of 24 per cent in the primary safety outcome.
Pradaxa, a direct thrombin inhibitor (DTI), was the first widely approved drug in a new generation of direct oral anticoagulants, available to address the high unmet medical need in the prevention and treatment of acute and chronic thromboembolic diseases.
I presume the manufacturer of the thromboplastin used in your laboratory has published the correlation tables between PT and INR for the ranges usually seen in patients receiving oral anticoagulants.