anticoagulant

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anticoagulant

(ăn'tēkōăg`yələnt), any of several substances that inhibit blood clot formation (see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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). Some anticoagulants, such as the coumarin derivatives bishydroxycoumarin (Dicumarol) and warfarin (Coumadin) inhibit synthesis of prothrombin, a clot-forming substance, and other clotting factors. The coumarin derivatives compete with vitamin K, which is a necessary substance in prothrombin formation (see vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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). They are only effective after the body's existing supply of prothrombin is depleted. Another anticoagulant, heparin, is a polysaccharide (see carbohydratecarbohydrate,
any member of a large class of chemical compounds that includes sugars, starches, cellulose, and related compounds. These compounds are produced naturally by green plants from carbon dioxide and water (see photosynthesis).
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) found naturally in many cells. It acts in several ways: by preventing prothrombin formation; by preventing formation of fibrin, another clotting substance; and by decreasing the availability of a third clotting factor, thrombin. Heparin is obtained by extracting it from animal tissues. Anticoagulants are used to treat blood clots, which appear especially frequently in veins of the legs and pelvis in bedridden patients. Therapy helps to reduce the risk of clots reaching the lung, heart, or other organs. Heparin causes an instantaneous increase in blood-clotting time, and its effect lasts several hours.

anticoagulant

[¦an·tē‚kō′ag·yə·lənt]
(pharmacology)
An agent, such as sodium citrate, that prevents coagulation of a colloid, especially blood.

anticoagulant

1. acting to prevent or impair coagulation, esp of blood
2. an agent, such as warfarin, that prevents or impairs coagulation
References in periodicals archive ?
Meanwhile, costs of oral anticoagulants rose sharply.
Novel oral anticoagulants and their role in clinical practice.
So it is obvious that there is an evident need to make a protocol for oral surgery procedures in patients on oral anticoagulant therapy.
Improved oral anticoagulants are a challenge and will be the goal of many researchers in the next few years.
These results suggest that oral anticoagulants such as coumadin can be monitored in the presence of a thrombin inhibitor by using the amidolytic factor X assay.
By addressing much of the variability worldwide--caused by different instruments and by varying brands and batche of thromboplastin--universal INR reporting will make it easier for travelers taking oral anticoagulants to remain in good control.
Direct-acting oral anticoagulants were evaluated in randomized clinical trials that were "often very large, of good quality and considered definitive in the field," Dr.
A comparison between six- and four-week intervals in surveillance of oral anticoagulant treatment.
Direct oral anticoagulants were evaluated in randomized clinical trials that were "often very large, of good quality, and considered definitive in the field," Dr.
Caption: Direct-acting oral anticoagulants had the best safety and efficacy on low-weight patients when used at the labeled dosages, said Dr.
Warfarin and direct-acting oral anticoagulants (DOACs) are most commonly used in the treatment of atrial fibrillation for the prevention of ischemic stroke and venous thromboembolism.
- US-based pharmaceutical company Verseon presented two lead candidates from its new class of precision oral anticoagulants (PROACs) at last week's International Stroke Conference in Honolulu, HI, the company said.