Organoid


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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Organoid

 

one of the permanent components of animal and plant cells. Each organoid performs specific functions that are vital for cell survival. Thus, any cell activity is a consequence of the coordinated operation of interconnected components, particularly organoids. Organoids include mitochondria, the Golgi apparatus, the centrosomes, the endoplasmic reticulum, ribosomes, and cytoplasmic microtubules. Organoids in plant cells include plastids and spherosomes. The classification of lysosomes as organoids is controversial. The term “organoid” derives from the similarity of these cell components to the organs of a multicellular organism. Organoids are contrasted to temporary cell inclusions, which appear and disappear in the metabolic process.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
"If you had asked me five years ago 'Would you think that a brain organoid would ever have a sophisticated network able to generate a brain oscillation?' I would say no," Alysson Muotri, a biologist at the University of California San Diego, told AFP.
Doctor Marianne Carlon, coordinator of the organoid research in Leuven, underlines the importance of the new approach: 'This technique requires the utmost precision.
Also, the novel compounds and patient-derived organoid platform allow the teams at RWJUH and Rutgers Cancer Institute to examine combination therapy and design individualized therapeutic strategies for GBM that relies on utilizing tailored combinations of targeted genetic-, epigenetic- and/or immune-modulating therapies.
An organoid is grown from stem cells and mimics an organ, which can be used to study that organ in the lab.
An organoid is a three-dimensional structure grown from stem cells that mimics an organ and can be used to study aspects of that organ in a petri dish.
They pointed to a study in which scientists noted "neural activity" after shining light on a region of a human "organoid" with eye and brain cells.
We also used a gastric organoid culture system to assess the mechanism(s) underlying inflammation-associated metaplasia and cancer.
10 [micro]l of complete organoid medium (a-MEM supplemented with 10% FBS and 1% Antibiotic-Antimycotics), and three CHACC particles were placed into each well of a Terasaki microplate (Greiner Bio-One, Stonehouse, UK) and incubated for 24 hours at 37[degrees]C under 5% C[O.sub.2] in air.
Thereafter, n = 3 animals from each group were euthanized using C[O.sub.2] chamber, and the whole small intestine (from duodenum to ileum) has been used for organoid formations.
"These organoid structures more closely resemble a living tumour in a person and can help us better understand different people's cancers and how drugs can be used to treat them."
Prof Borri said: "We use laser-light which will enable us to view a 3D organoid in a way which has never been done before.
Furthermore, we describe recent advances in small intestinal organoid techniques, including coculture with immune cells, which offer an exciting opportunity to develop state-of-the-art in vitro models for CD research.