Organoid


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Organoid

 

one of the permanent components of animal and plant cells. Each organoid performs specific functions that are vital for cell survival. Thus, any cell activity is a consequence of the coordinated operation of interconnected components, particularly organoids. Organoids include mitochondria, the Golgi apparatus, the centrosomes, the endoplasmic reticulum, ribosomes, and cytoplasmic microtubules. Organoids in plant cells include plastids and spherosomes. The classification of lysosomes as organoids is controversial. The term “organoid” derives from the similarity of these cell components to the organs of a multicellular organism. Organoids are contrasted to temporary cell inclusions, which appear and disappear in the metabolic process.

References in periodicals archive ?
Dalya Abdel-Atti presented research showing that using a HuMab 5B1 based PET imaging agent produced high-quality images in a pancreatic cancer murine organoid model even in the presence of shed antigen.
A new, straightforward ex vivo organoid bladder mucosal model for preclinical research.
Professor Rene Anand of the US Ohio State University said: "These human brain organoid models will allow us to study how exposure to drugs of abuse in utero, such as in pregnant nicotine users, alters the early brain development of the foetus and how human gene variants contribute to neurological disorder susceptibility.
July 16 (SeeNews) - Belgian biotechnology firm Galapagos (AMS:GLPG) said Wednesday it had signed a licence agreement with the HUB foundation to use its Organoid Technology for pre-clinical research in cystic fibrosis (CF) and inflammatory bowel disease (IBD).
Histologic analysis demonstrated sheets, strands, and nests of two types of cells: gland-forming acini-like and squamous cells in an organoid arrangement.
The use of whole organ decellularization for the generation of a vascularized liver organoid.
If a suspected choristomas main component is an exuberant organoid respiratory epithelium and if the salivary glands represent the result of a successive metaplastic change, then the term hamartoma appears to be a more appropriate description of the lesion.
The cells do not thrive and develop if they are alone, and a minimum of four pancreatic cells close together is required for subsequent organoid development.
He said the organoid was "audacious and the similarities with some of the features of a human brain really quite astounding".
The tissue, dubbed a cerebral organoid, doesn't approach the dizzying complexity of the human brain.
Some areas presented an organoid or epithelioid pattern with nests of neoplastic cells (Figure 1, B).
Methods include pancreatic islets, endometrial organoid culture, modeling lymphatic and blood capillary patterning, precision-cut lung slices, human colon tissue in organ culture, fetal organs culture, magnetic assembly of tissue surrogates, and assembly of renal tissues by cellular self-organization.