Mutations and polymorphisms in the human ornithine
2]S - - - production Acetamidase + NA - NA Nitrate reduction + + - NA [alpha]-Methyl- - - + + D-glucoside Indole + + + + DNA - + - NA Arginine - - - dihydrolase Ornithine
- + + + decarboxylase Lysine + + + 4- decarboxylase Growth at NaCl 0% 1% + + + + 3% + + + + 6% + + + + 0/129 10 [micro]g S S S s 150 [micro]g S s s s +, positive; negative; F, fermentative; NA, not available; S, sensitive; v, variable between strains.
Elam RP, Hardin DH, Sutton RA, Hagen L (1989) Effects of arginine and ornithine
on strength, lean body mass and urinary hydroxyproline in adult males.
Four of the seven identified metabolites--histidine, arginine, ornithine
and glutamine--are related to genes involved in arginine-glutamine metabolism and nitrogen compound biosynthesis.
Cpn60) (groEL protein )/85 pyogenes (67) M3 8 Ornithine
Tamir and Ratner (1963) attributed birds' incapacity to synthesize ornithine
, citrulline and Arg to the absence of another enzyme key to the urea cycle, ornithine
carbamoyltransferase (Figure 2).
The concentrations of the amino acids cysteine, methionine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine, histidine, ornithine
, lysine, arginine, hydroxyproline, tryptophan and taurine were nearly identical in kapenta compared to FPC (Table 1).
Measurement of OAT activity: The activity of ornithine
aminotransferase (OAT) was determined as described by Wu et al.
The peak separation is >95% on common amino acids profile (up to 45 amino acids in a single run with Lithium systems), including Taurine, Ornithine
, oxidized amino acids such as Cysteic acid and Methionine Sulfone, and hydroxylated amino acids such as Hydroxyproline and Hydroxylysine.
Jesse, who was eighteen years old, was participating in a phase I safety study of a gene transfer therapy for ornithine
transcarbamylase deficiency (OTCD), a rare metabolic condition.
In particular, for ameliorating the symptoms or onset of amyotrophic lateral sclerosis (ALS) by modulating the gene and protein products involved the polyamine pathway, such as by inhibiting the enzyme, ornithine
decarboxylase (ODC), involved in the synthesis of the polyamine, putrescine.
beverage called Office Diet, formulated with carnitine, ornithine