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A bone-forming cell of mesenchymal origin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a cell that is involved in bone formation in vertebrate animals and man. Osteoblasts arise during the ossification of skeletal rudiments. In mature bone, they are found only in regions of injury, regeneration, and remodelling. They also take part in the formation and calcification of the intercellular substance of a bone.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Osteoblast specific gene expression detected by RTPCR.
The BMP receptors are a family of transmembrane serine/threonine kinases that include the type I receptors Bmpr1a and Bmpr1b , and the type II receptor Bmpr2 .[20] Deletion of the receptor Bmpr1a in the osteoblast lineage cells with a Dmp1 -Cre caused a dramatic increase in trabecular bone mass in postnatal mice, which was due to a marked increase in osteoblast numbers.
Type I collagen, alkaline phosphatase, and calcium deposition are well-known molecular markers for osteoblast maturity.
In particular, we observed the presence of cytoplasmic vesicles containing HA granules in prostate cancer cells showing osteoblast phenotype (POLCs) [24, 40-42].
[15] (GSE54461, nine time points: 2, 4, 6, 8, 10, 12, 14, 16, and 18 days of osteoblast differentiation).
The result indicated that [gamma]-tocotrienol at low dosage could indirectly regulate the activation of osteoblast proliferation and was consistent with MTT results.
In a recent study, it was also shown to inhibit ST2 cell differentiation toward the osteogenic linage by directly targeting lysine-specific demethylase 6b (Kdm6b), a regulator of osteoblast differentiation [46].
After surface characteristic evaluation of the different Ti samples, we further testify the effects of different Ti samples on osteoblast behavior.
Although few studies have described osteoblastic apoptosis induced by TNF[alpha] and IFN[gamma] costimulation in cell lines other than MC3T3-E1, a previous study has shown that stimulation of rat osteoblast cell line ROS 17/28 with a mixture of TNF[alpha], IFN[gamma], and LPS induced apoptosis [34].
Bone is a dynamic tissue in which three cell types, osteoclasts, osteoblasts and osteocytes, regulate its homeostasis by constant resorption and deposition of the mineral components and structural realignment and remodeling of its matrix in response to biochemical and mechanical signals.