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A bone-forming cell of mesenchymal origin.



a cell that is involved in bone formation in vertebrate animals and man. Osteoblasts arise during the ossification of skeletal rudiments. In mature bone, they are found only in regions of injury, regeneration, and remodelling. They also take part in the formation and calcification of the intercellular substance of a bone.

References in periodicals archive ?
In addition, the researchers showed that Cbf-beta maintains the osteoblast lineage commitment in two ways: through the Wnt paracrine pathway to affect nearby cells and through endogenous signaling within the cell to suppress adipogenesis gene expression.
Alkaline phosphatase and production of collagen are extensively recognized indicators for osteoblast function25 and their concentration increases with zinc supplementation.
Exposure of periodontal ligament progenitor cells to lipopolysaccharide from Escherichia coli changes osteoblast differentiation pattern.
For example, amlodipine, an L-type VSCC blocker, is used to treat MC3T3-E1 (immoral osteoblast cell line) and MLO-Y4 (immoral osteocyte cell line) cells showing a prolonged declining of calcium in both types of cells, while treatment of NNC55-0396 (T-type VSCC blocker) can discontinue the repetitive influx calcium in MLO-Y4 cells after inducing an immediate spike, and it had no observable effects on MC3T3-E1 cells.
11) In a study, quercetin inhibited osteoblast proliferation, differentiation, and mineralization.
The in vitro experiments with osteoblast precursor cells indicated that both lead and fatty acids altered factors that influence Wnt signaling.
OCS inhibit osteoblast maturation, secretion and transformation into osteocytes.
Rucinski et al [24] investigated the effects of estradiol and some resveratrol like silymarin on osteocalcin gene expression in Osteoblasts primary cells and found that despite estradiol, Silymarin could not alter osteocalcin gene expression in osteoblast primary cells.
29 This signal molecule en- hances vascular invasion stimulates proliferation of osteoblast precursors and promotes mineralization of new bone by osteoblasts.
13] that reported increase in normal osteoblast and reduction in osteosarcoma cells after treating with LLLT with 830 nm wavelengths and total energy impact of 10 J/cm2.
Wnt/[beta]-catenin signaling plays significant roles in both embryonic development and tumorigenesis, and when activated induces differentiation of mesenchymal cells with pluripotential into osteoblast progenitors to become osteoblasts.