NFATc1 translocates to the nucleus and induces the expression of multiple osteoclast
markers, such as tartrate-resistant acid phosphatase (TRAP), cathepsin K, and cellular tyrosine protein kinase-Src (c-Src) (Boyle et al.
Intriguingly, humans with cathepsin K mutations have skeletal hypermineralization and increased fracture risk, with bone biopsies demonstrating normal or increased osteoclast
Key Words: Diabetes Mellitus, Orthodontic Tooth Movement, Osteoclast
, Bone Remodeling.
malfunction resulting in primary sclerosing conditions of bone must be differentiated from several conditions wherein bone sclerosis results as a secondary phenomenon.
Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast
formation and resorption in vitro.
Osteoblasts regulate osteoclast
activity through the secretion of RANKL.
24) With the background that RANKL/RANK signaling is essential for osteoclast
formation, major studies have focused on the area to determine the full extent of the involvement of RANKL in osteoclast
biology and common bone diseases.
In 2007, a novel study was conducted by Simpson et al, in which they used mature osteoclasts
to demineralize calcified elastin in vitro and in vivo .
formation and tartrate-resistant acid phosphatase (TRAP) staining
Downregulation of TNF-[alpha] levels was important for expression of RANKL, which was critical for osteoclast
differentiation and function.
5) Odanacatib appears to mainly suppress bone resorption with only a transient effect on bone formation and does not seem to impact osteoclast
By targeting the receptor activator of nuclear factor-kappaB ligand (RANKL), which is the primary mediator of osteoclast
formation, denosumab blocks the production of the bone-destroying osteoclasts
and by so doing improves the density, volume, and strength of both cortical and trabecular bone, according to the authors (N.