Knock-down of RANKL can effectively reduce the osteoclast
formation compared with over-expression of RANKL.
Drugs used to treat OP including BP can alleviate pain by acting on osteoclast
Moreover, recombinant Annexin A2 protein showed an increase in transendothelial migration of monocytes in vitro, besides its known function in osteoclast
co-cultures on silk fibroin, chitosan and PLLA films.
Takayanagi, "New immune connections in osteoclast
formation," Annals of the New York Academy of Sciences, vol.
Mundy, "Advances in osteoclast
biology: old findings and new insights from mouse models," Nature Reviews Rheumatology, vol.
* Bone is removed from areas where it is less needed through the actions of cells called osteoclasts
, which break down the bone matrix and resorb the minerals.
Biochemical analyses were performed in triplicate at intervals of 24, 48 and 72 h Osteoclast
activity was evaluated by dosing the calcium level in the medium culture collected at each interval using Total Calcium LiquiColor kit (Stanbio, USA) and reading absorbance in a spectrophotometer at 550 nm.
The effects of liensinine and nuciferine on the activity of mature osteoclasts
were investigated in BMMs treated with liensinine or nuciferine at noncytotoxic concentrations for 2 additional days after the induction of osteoclast
differentiation by RANKL stimulation for 5 days.
IL-27 Is an Antagonist of the IL-6/-11 Axis, Promotes Osteoblast Differentiation, and Reduces Osteoclast
shown in Figure 5 showed significant differences in week 1 in all groups (p < 0.05) and also in week 4 in control, bovine hydroxyapatite, and freeze-dried cortical bovine groups (p < 0.05).
The pathogenesis of periprosthetic osteolysis involves the production of proinflammatory cytokines, osteoclast
activation, and bone loss after wear particle stimulation [1, 6].