Osteoclast


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osteoclast

[′äs·tē·ə‚klast]
(histology)
A large multinuclear cell associated with bone resorption.
(medicine)
A large surgical apparatus through which leverage can be exerted to effect osteoclasis.

Osteoclast

 

a cell that is involved in the destruction and resorption of bone tissue in vertebrate animals and man. An osteoclast contains from three to several dozen nuclei and a great many lysosomes, whose hydrolytic enzymes upon release from the osteoclasts resorb the mineral matrix of bone and calcified cartilage.

References in periodicals archive ?
Knock-down of RANKL can effectively reduce the osteoclast formation compared with over-expression of RANKL.
Drugs used to treat OP including BP can alleviate pain by acting on osteoclast activity.
Moreover, recombinant Annexin A2 protein showed an increase in transendothelial migration of monocytes in vitro, besides its known function in osteoclast formation [38].
Osteoblast: osteoclast co-cultures on silk fibroin, chitosan and PLLA films.
Takayanagi, "New immune connections in osteoclast formation," Annals of the New York Academy of Sciences, vol.
Mundy, "Advances in osteoclast biology: old findings and new insights from mouse models," Nature Reviews Rheumatology, vol.
* Bone is removed from areas where it is less needed through the actions of cells called osteoclasts, which break down the bone matrix and resorb the minerals.
Biochemical analyses were performed in triplicate at intervals of 24, 48 and 72 h Osteoclast activity was evaluated by dosing the calcium level in the medium culture collected at each interval using Total Calcium LiquiColor kit (Stanbio, USA) and reading absorbance in a spectrophotometer at 550 nm.
The effects of liensinine and nuciferine on the activity of mature osteoclasts were investigated in BMMs treated with liensinine or nuciferine at noncytotoxic concentrations for 2 additional days after the induction of osteoclast differentiation by RANKL stimulation for 5 days.
IL-27 Is an Antagonist of the IL-6/-11 Axis, Promotes Osteoblast Differentiation, and Reduces Osteoclast Formation.
The pathogenesis of periprosthetic osteolysis involves the production of proinflammatory cytokines, osteoclast activation, and bone loss after wear particle stimulation [1, 6].