Osteodystrophy


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osteodystrophy

[‚äs·tē·ō′di·strə·fē]
(medicine)
Any defective bone formation, as in rickets or dwarfism.

Osteodystrophy

 

any one of a group of bone diseases that are characterized by deformity of different parts of the skeleton owing to metabolic disorders. Osteodystrophy can be parathyroid, deforming, local fibrous, toxic, or related to diseases of the internal organs; the first two types are the commonest. Spontaneous bone resorption is the extreme type of osteodystrophy.

Parathyroid osteodystrophy is an endocrine disease that develops with parathyroid tumors and with the release of excess quantities of parathyroid hormone. Considerable resorption occurs throughout the skeleton. The treatment is surgical, involving resection of the parathyroid gland. Unlike parathyroid osteodystrophy, deforming osteodystrophy affects one or only a few bones. The pathogenesis of deforming osteodystrophy is unknown, and treatment is symptomatic. Deforming osteodystrophy is conducive to the development of osteosarcomas.

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A 64-year-old female with long-standing end-stage renal disease (ESRD), (3) status post 2 failed renal transplants, was evaluated for management of renal osteodystrophy with particular concern for adynamic bone disease (ABD).
A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations
It was then that we proceeded with collecting the Vitamin D 11.5ng/dl (normal range 2575ng/dl), Calcium 6.9 mg/dl(8.5-10.5 mg/dl), Phosphorous 8.6 mg/dl (2.8-5 mg/dl), Alkaline phosphatase 769 U/litre (30-135 U/litre) and Parathyroid Hormone 46.2 pg/ml (8.8-76.6 pg/ml) levels and finally arrived at the conclusion that the patient was a case of Renal Osteodystrophy (low turnover type).
Spontaneous simultaneous bilateral femoral neck fracture secondary to renal osteodystrophy: a case report & review of literature
Renal osteodystrophy has traditionally been the most commonly cited morbidity associated with CKD-MBD.
Mineral and bone disorders in patients on dialysis: physiology and clinical consequences
Renal osteodystrophy commonly results in bone pain and fractures, both of which increase in frequency and severity as CKD progresses.
Consequences of chronic kidney disease--mineral and bone disorder: a progressive disease
Epigenetic defects of GNAS in patients with pseudohypoparathyroidism and mild features of Albright's hereditary osteodystrophy. J Clin Endocrinol Metab 2007;92:2370-3.
Pseudohypoparathyroidism Type la with Normocalcemia
A 22-year-old woman with hypocalcemia and clinical features of Albright hereditary osteodystrophy diagnosed with sporadic pseudohypoparathyroidism type Ib using a methylation-specific multiplex ligation-dependent probe amplification assay.
Discordant Calcium and Parathyroid Hormone with Presumed Epileptic Seizures
PHP type 1a is characterized by the expression of the Gs[alpha] isoform only of the paternal GNAS gene, with resistance to other hormones rather than PTH and by the phenotype of Albright's hereditary osteodystrophy (AHO) with round facies, short stature, obesity, subcutaneous ossifications, brachydactyly, and in some cases mental retardation [3-5].
Identification of a Novel Mutation in a Family with Pseudohypoparathyroidism Type 1a
X-ray of the maxilla and mandible showed diffused decreasing bone density and multiple lytic lesion, which suggest metabolic bone disease or renal osteodystrophy or hyperparathyroidism (Figure 6).
Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital
Other entities associating ectodermal and skeletal phenotypes were reviewed, particularly Albright osteodystrophy, acrodysostosis, and other brachydactyly syndromes, but several features of the presentation were inconsistent with these diagnoses.
Dysmorphic Short Stature: Radiological Diagnosis of Trichorhinophalangeal Syndrome
Renal osteodystrophy is defined by the abnormalities of bone turnover, mineralization, and microarchitecture that affect CKD patients.
Role of the Wnt/[beta]-Catenin Pathway in Renal Osteodystrophy
Selected skeletal dysplasias: craniomandibular osteopathy, multiple cartilaginous exostoses and hypertrophic osteodystrophy. Veterinary Clinics of North America: Small Animal Practice 13, 55-70.
Calvarial Hyperostosis Syndrome in an American Pit Bull/Terrier/Amerikan Pit Bull Terrier bir Kopekte Calvarial Hiperosteozis Sendromu

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