Osteodystrophy


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osteodystrophy

[‚äs·tē·ō′di·strə·fē]
(medicine)
Any defective bone formation, as in rickets or dwarfism.

Osteodystrophy

 

any one of a group of bone diseases that are characterized by deformity of different parts of the skeleton owing to metabolic disorders. Osteodystrophy can be parathyroid, deforming, local fibrous, toxic, or related to diseases of the internal organs; the first two types are the commonest. Spontaneous bone resorption is the extreme type of osteodystrophy.

Parathyroid osteodystrophy is an endocrine disease that develops with parathyroid tumors and with the release of excess quantities of parathyroid hormone. Considerable resorption occurs throughout the skeleton. The treatment is surgical, involving resection of the parathyroid gland. Unlike parathyroid osteodystrophy, deforming osteodystrophy affects one or only a few bones. The pathogenesis of deforming osteodystrophy is unknown, and treatment is symptomatic. Deforming osteodystrophy is conducive to the development of osteosarcomas.

References in periodicals archive ?
The etiology of this patient's osteodystrophy could not be confirmed, and a hereditary component cannot be ruled out; however, an inadequate diet likely played a significant role.
This case is another example where the radiologist may offer a definitive diagnosis (renal osteodystrophy with secondary hyperparathyroidism) based on diagnostic radiographic features aiding further clinical management.
The histopathological examination of the femur also showed evidence of osteoclastic and osteolytic activity leading to osteodystrophy.
Cadmium toxicity to ringed seals (Phoca hispida)--an epidemiological study of possible cadmium induced nephropathy and osteodystrophy in ringed seals (Phoca hispida) from O.
The hemodialysis treatment process itself creates a new clinical pathology which includes uremic cardiomyopathy, renal osteodystrophy, and dialysis dementia (Funck-Brentano 1980).
The unmet medical need is compelling - elevated PTH exacerbates mineral imbalances (particularly calcium and phosphorus) in ESRD patients, and is linked to severe pathological effects such as osteodystrophy, vascular calcification, and increased risk for cardiovascular events, all of which contribute to morbidity and mortality in these patients.
Irrespective of the cause, the high level of PTH observed with primary or secondary hyperparathyroidism increases osteoclast activity, which eventually leads to osteodystrophy.
Aim: We planned this study in order to evaluate the radiological and biochemical parameters that may be useful in the early diagnosis of renal osteodystrophy in the patients with chronic renal failure, prospectively.
Phosphate retention and the resulting hyperphosphatemia in patients with ESRD on dialysis are usually associated with secondary hyperparathyroidism, renal osteodystrophy, soft tissue mineralization and the progression of renal failure.
Consequently, bone structure is weakened this condition is called Renal Osteodystrophy or Renal Bone Disease.
The differential diagnoses included osteopetrosis, Paget disease, hyperparathyroidism, renal osteodystrophy, osteomalacia, and skeletal fluorosis.