Osteomalacia


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Related to Osteomalacia: Paget's disease

osteomalacia

[¦äs·tē·ō·mə′lā·shə]
(medicine)
Failure of bone to ossify due to a reduced amount of available calcium. Also known as adult rickets.

Osteomalacia

 

a bone disease that is manifested by softening and deformity of bone as a result of disturbances in mineral metabolism; usually, the depletion of calcium salts, phosphoric acid, and vitamin D is the cause. Osteomalacia generally occurs in women, especially during pregnancy, in which case the pelvic bones and adjacent portions of the skeleton are particularly affected. Recovery occurs in the postpartum period. Bones may remain permanently deformed after osteomalacia as a result of calcification.

REFERENCE

“Osteomaliatsiia.” In Bol’shaia meditsinskaia entsiklopediia, 2nd ed., vol. 22, Moscow, 1961.
In animals. Osteomalacia in animals is manifested clinically by a decreased and unusual appetite, during which the animal exhibits pica and eats inedible objects. Other symptoms are emaciation and lowered productivity, lameness, loose teeth, sluggishness, curvature or sagging of the spinal column, and bone fractures. The diagnosis is based on analysis of the mineral and vitamin D content of feed; the calcium, phosphorus, and phosphatase content of blood; and roentgenograms of the tail vertebrae. Osteomalacia in animals is prevented by exercise, by regular checks of the feed and inclusion of optimum quantities of minerals and vitamins, and by ultraviolet irradiation while the animals are in their stalls.

REFERENCE

Vnutrennie nezaraznye bolezni zhivotnykh. Edited by A. M. Kolesov. Leningrad, 1972.
References in periodicals archive ?
Segundo Harris e Colaboradores; Webb, Kline e Holick citado por Premaor e Furnalleto (2006), ha um numero maior de deficiencia de vitamina D em negros americanos, apresentando osteomalacia e hiperparatireoidismo secundario.
Excessive paraneoplastic production of phosphatonin is thought to be involved in the etiology of tumor-induced osteomalacia, whereas impaired degradation and processing of phosphatonin due to endopeptidase mutations (PHEX gene: phosphate-regulating gene with homologies to endopeptidases on the X chromosome) is thought to cause the typical findings in XLH.
People likely to develop osteomalacia tend to keep their body covered or stay indoors and so don't have exposure to sunlight and vitamin D.
In contrast, osteomalacia can cause muscle weakness as well as bone ache and bone pain.
Iliac crest bone biopsy revealed no osteomalacia but moderate osteoporosis with normal trabecular volume but decreased osteoid surfaces and osteoid volume and increased mineral apposition rate (Table II).
In older people, a vitamin D shortfall increases the severity of osteoporosis (loss of bone mass) and the risk of osteomalacia (softening of the bones, an adult form of rickets).
Vitamin D deficiency can result in rickets in children (rarely) or low blood calcium levels and a more common softening and brittleness of the bones, osteomalacia, which occurs in adults and chiefly in women.
Specific nutrient deficiency diseases like goitre, anemia and osteomalacia will be prevented by dietary and non-dietary measures.
Chef Sanjiv Verma, Vice President , CAFR unveiled a research paper on this special breed of poultry underscoring that this particular breed of poultry is said to have been curing, pulmonary problems tuberculosis (TB), heart diseases, neurasthenia ( a condition of nervous debility supposed to be dependent upon impairment in the functions of the spinal cord), and children osteomalacia ( a condition marked by softening of the bones).
The main bone features include a low bone formation rate and a defect in bone mineralization, which was severe cases leads to osteomalacia.
Keywords: Bone health, musculoskeletal health, osteomalacia, osteoporosis, rickets, Pakistan, South Asia.
Based on the above findings, the patient was diagnosed with osteomalacia secondary to hypophosphatemia.