methotrexate

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Related to Otrexup: methotrexate

methotrexate,

drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemialeukemia
, cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature leukocytes (white blood cells; see blood) and consequently a crowding-out of red blood cells and platelets.
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, psoriasispsoriasis
, occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells.
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, and non-Hodgkin's lymphomalymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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. By binding to an enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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 that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acidsnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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 and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritisarthritis,
painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder.
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.

methotrexate

[‚meth·ə′trek‚sāt]
(pharmacology)
References in periodicals archive ?
OTREXUP was the first US FDA-approved subcutaneous methotrexate for once weekly self-administration with an easy-to-use, single dose, disposable auto injector for adults with severe active rheumatoid arthritis who have had an insufficient therapeutic response to or are intolerant of an adequate trial of first line therapy including full dose non-steroidal anti-inflammatory agents, added the company.
Antares president and CEO, Dr Paul K Wotton, stated that Otrexup offers an attractive new option that is likely to benefit patients who have had an inadequate response to, or are intolerant of, oral methotrexate.
Antares Pharma, a company that develops, manufactures and markets needle-free injection systems for the self-administration of parenteral drugs, has received approval for OTREXUP, a single-dose, disposable auto-injector for the subcutaneous once-weekly administration of methotrexate from the US Food and Drug Administration (US FDA), it was reported yesterday.
The company stated that the claims in the OTREXUP patent are directed toward an injection system for methotrexate as well as a method for treating rheumatoid arthritis and other autoimmune diseases using an auto-injector or similar device for subcutaneous delivery of methotrexate.
The NDA submission of OTREXUP represents yet another significant accomplishment in the Company's history," said Paul K.
M2 EQUITYBITES-February 28, 2013-Antares Pharma Inc's OTREXUP NDA accepted by US FDA for review(C)2013 M2 COMMUNICATIONS http://www.
M2 PHARMA-February 28, 2013-Antares Pharma Inc's OTREXUP NDA accepted by US FDA for review(C)2013 M2 COMMUNICATIONS