Sharma, Synthesis and biocidal activity of some substituted oxadiazoles
, thiadiazoles and triazoles, Indian J.
Mishra, Synthesis of Some Novel Oxadiazole
and Oxadiazoline Analogues for their Anti-Inflammatory Activity, J.
Synthesis, Characterization, Antioxidant, Antimicrobial, Cytotoxic, Anticancer, Leishmanicidal, Anti-inflammatory Activities and Docking Studies of Heterocyclic 1,3,4-oxadiazoles and 4-amino-1,2,4-triazoles Derivatives
Pitsas, Synthesis of Novel Sulfonamide-1,2,4- Triazoles, 1,3,4-Thiadiazoles and 1,3,4- Oxadiazoles
, as Potential Antibacterial and Antifungal Agents: Biological Evaluation and Conformational Analysis Studies.
The significant biological activities of 1,3,4- Oxadiazoles
, amides and Schiff bases prompted us to synthesize some new molecules bearing all these functionalities.
Khan and Atta-Ur-Rahman, Kinetics of Novel Competitive Inhibitors of Urease Enzymes by a Focused Library of Oxadiazoles
/ Thiadiazoles and Triazoles, Biochem.
e 124 oxadiazoles
which have engrossed the interest of researcher due to their worth importance in the field of material sciences polymer insecticidal and medicinal .
Due to medicinal importance and in continuation of our previous research work on 1,3,4- Oxadiazoles
[9-12], the 2,5-disubstituted-1,3,4- Oxadiazole
derivatives were synthesized with an objective to detect the biological potential.
Polymers containing 1,3,4-oxadiazole
rings present a great interest for high performance materials because of their high thermal stability and certain specific properties that are determined by the nature of oxadiazole
unit that has a strong electron-withdrawing character [1, 2], Poly(arylene-oxadiazole
)s give easily redox reactions, chemically or electrochemically, and the resulting materials are good candidates for electrochemical sensors or electroluminescent devices, to be used in optoelectronics, microelectronics, or other advanced fields [3, 4].
Poly(aryleneoxadiazole)s, which are of special interest for the production of advanced materials due to their high thermal oxidative stability and specific properties, are determined by the electron withdrawing nature of oxadiazole
In the FTIR spectrum of compound C (-l), absorption peaks at 1520 and 1340 cm (-1) are due to the asymmetric and symmetric stretching vibrations of nitro groups, and weak bands located at 1553 and 956 cm (-1) correspond to the stretching vibration of C=N and C--O--C in oxadiazole
ring, respectively (35).
In this study, it was planned to incorporate the oxadiazole
ring system into tetrazole ring, as it has not been reported earlier.
Our aim was to synthesize the new chemical entities derived from santonin with oxadiazole
moiety and to evaluate them for the antimicrobial activities.