Oxidoreductases


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Related to Oxidoreductases: Hydrolases, Transferases

Oxidoreductases

 

the class of enzymes that catalyze oxidation-reduction reactions. Oxidoreductases are present in all living cells. The oxidized substrates that oxidoreductases act on can be a hydroxyl group (—OH), aldehyde group (—CHO), ketone group (> CO), or ethyl group (—CH2—CH2—). This class of enzymes also acts on reduced forms of pyridine coenzymes, for example, nicotinamide-adenine dinucleotide (NAD) and nicotinamide-adenine dinucleotide phosphate (NADP). Among the substances that are reduced in an oxidoreductase reaction, that is, among those that serve as acceptors of hydrogen and electrons, are NAD, NADP, cytochromes, lipoic acid, and quinones. The most important oxidoreductases include dehydrogenases, which transfer hydrogen and electrons during respiration and photosynthesis; oxidases, with the oxidizing agent O2; peroxidases, with the oxidizing agent H2O2; hydroxylases, which incorporate one atom of O2 into a molecule of substrate; and oxygenases, which incorporate two atoms of O2 into a molecule of substrate. More than 200 oxidoreductases are known.

References in periodicals archive ?
Present investigations prove altered activity of few oxidoreductases leading to functional impairment of placental tissue following early gestational maternal malarial infection.
This gains support from the findings of Breuer et al (24) who correlated threatened abortions as well as foetal growth retardations with low levels of the oxidoreductases.
In conclusion, changes in distribution pattern of oxidoreductases in placenta following early gestational malaria have posed severe threat to maternal-foetal well-being which is thought to be responsible for foetal deaths and abortions (15-18) in infected monkeys.
It is well known that NAD(P)H:quinone oxidoreductase (NQ01) activity is the principal determinant of [beta]-Lapachone cytotoxicity.
It is well known that the enzyme NAD(P)H:quinone oxidoreductase 1 (NQ01) is the principal determinant of [beta]-Lapachone cytotoxicity.
We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor [alpha] (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor [beta]2 (ADRB2)].
Polymorphisms in oxidative stress genes NAD(P)H:quinine oxidoreductase [NQO1, GeneID 1728 (Entrez Gene 2008)] and gluthatione S-transferases M1 [GSTM1, GeneID 2944 (Entrez Gene 2008)] and P1 [GSTP1, GeneID 2950 (Entrez Gene 2008)] have been associated with a decrease on pulmonary function (Bergamaschi et al.
3) Studies have demonstrated that pheochromocytoma-paraganglioma syndrome is a hereditary condition frequently associated with PGs caused by germ line mutations in the SDHB, SDHC, or SDHD genes, encoding 3 of the 4 subunits of mitochondrial complex II, the succinate-ubiquinone oxidoreductase (succinate dehydrogenase [SDH]).
The major players in mitoROS production are complexes I and III of the mitochondrial ETC [18], although other ROS-producing mitochondrial sites include mitochondrial glycerol-3-phosphate dehydrogenase, the electron-transferring flavoprotein/ETF: ubiquinone oxidoreductase system of fatty acid oxidation, dihydroorotate dehydrogenase, the dihydrolipoamide dehydrogenase, and 2-oxoacid dehydrogenase complexes.
Lemire, "The ubiquinone-binding site of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase is a source of superoxide2," Journal of Biological Chemistry, vol.
Regulation of human NAD(P)H:quinone oxidoreductase gene.
MetZymeA is an enzyme solution developed by MetGen, based on thermostabile oxidoreductase enzymes with wide pH tolerance, designed for harsh industrial conditions.