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Present investigations prove altered activity of few oxidoreductases leading to functional impairment of placental tissue following early gestational maternal malarial infection.
This gains support from the findings of Breuer et al (24) who correlated threatened abortions as well as foetal growth retardations with low levels of the oxidoreductases.
It is well known that the enzyme NAD(P)H:quinone oxidoreductase 1 (NQ01) is the principal determinant of [beta]-Lapachone cytotoxicity.
Effect of PDT on NAD(P)H:quinone oxidoreductase levels in MCF-7c3 cells
Polymorphisms in oxidative stress genes NAD(P)H:quinine oxidoreductase [NQO1, GeneID 1728 (Entrez Gene 2008)] and gluthatione S-transferases M1 [GSTM1, GeneID 2944 (Entrez Gene 2008)] and P1 [GSTP1, GeneID 2950 (Entrez Gene 2008)] have been associated with a decrease on pulmonary function (Bergamaschi et al.
Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma.
This collaboration validates Triad's novel approach to small-molecule drug development and extensive work in the oxidoreductase gene family.
The first step was to computationally mine databases for small molecule mimics of the NADH cofactor, which bind across the entire family of oxidoreductases, and would occupy the first of two binding sites.
We are close to the completion of our first gene family collection of small molecule high-affinity lead compounds for the oxidoreductases and are making significant progress with the kinase gene family.
Regulation of human NAD(P)H:quinone oxidoreductase gene.
MetZymeA is an enzyme solution developed by MetGen, based on thermostabile oxidoreductase enzymes with wide pH tolerance, designed for harsh industrial conditions.