Oxidoreductases


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Related to Oxidoreductases: Hydrolases, Transferases

Oxidoreductases

 

the class of enzymes that catalyze oxidation-reduction reactions. Oxidoreductases are present in all living cells. The oxidized substrates that oxidoreductases act on can be a hydroxyl group (—OH), aldehyde group (—CHO), ketone group (> CO), or ethyl group (—CH2—CH2—). This class of enzymes also acts on reduced forms of pyridine coenzymes, for example, nicotinamide-adenine dinucleotide (NAD) and nicotinamide-adenine dinucleotide phosphate (NADP). Among the substances that are reduced in an oxidoreductase reaction, that is, among those that serve as acceptors of hydrogen and electrons, are NAD, NADP, cytochromes, lipoic acid, and quinones. The most important oxidoreductases include dehydrogenases, which transfer hydrogen and electrons during respiration and photosynthesis; oxidases, with the oxidizing agent O2; peroxidases, with the oxidizing agent H2O2; hydroxylases, which incorporate one atom of O2 into a molecule of substrate; and oxygenases, which incorporate two atoms of O2 into a molecule of substrate. More than 200 oxidoreductases are known.

References in periodicals archive ?
Present investigations prove altered activity of few oxidoreductases leading to functional impairment of placental tissue following early gestational maternal malarial infection.
This gains support from the findings of Breuer et al (24) who correlated threatened abortions as well as foetal growth retardations with low levels of the oxidoreductases.
It is well known that the enzyme NAD(P)H:quinone oxidoreductase 1 (NQ01) is the principal determinant of [beta]-Lapachone cytotoxicity.
Effect of PDT on NAD(P)H:quinone oxidoreductase levels in MCF-7c3 cells
Polymorphisms in oxidative stress genes NAD(P)H:quinine oxidoreductase [NQO1, GeneID 1728 (Entrez Gene 2008)] and gluthatione S-transferases M1 [GSTM1, GeneID 2944 (Entrez Gene 2008)] and P1 [GSTP1, GeneID 2950 (Entrez Gene 2008)] have been associated with a decrease on pulmonary function (Bergamaschi et al.
Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma.
TABLE 51 WORLDWIDE MARKET FOR OXIDOREDUCTASES BY REGION, THROUGH 2015 ($ MILLIONS)
This collaboration validates Triad's novel approach to small-molecule drug development and extensive work in the oxidoreductase gene family.
The first step was to computationally mine databases for small molecule mimics of the NADH cofactor, which bind across the entire family of oxidoreductases, and would occupy the first of two binding sites.
We are close to the completion of our first gene family collection of small molecule high-affinity lead compounds for the oxidoreductases and are making significant progress with the kinase gene family.
Regulation of human NAD(P)H:quinone oxidoreductase gene.
MetZymeA is an enzyme solution developed by MetGen, based on thermostabile oxidoreductase enzymes with wide pH tolerance, designed for harsh industrial conditions.