serine protease

(redirected from Oxyanion hole)
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serine protease

[¦se‚rēn ′prōd·ə‚ās]
(cell and molecular biology)
A family of endopeptidases whose proteolytic activity involves the hydroxy group of the serine residue; they play an important role in digestion, blood clotting, and the complement system.
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The following conserved motifs are present: (1) catalytic triad, (2) nucleophilic elbow, (3) a flap covering active site of Leu 226-Ile257, (4) beta9 loop, (5) beta5 loop and (6) Oxyanion hole (Fig.
Both of them are responsible for the formation of oxyanion hole during the enzymatic activation on binding of the substrate and makes strong H-bonds with the substrate.
The existence of that oxyanion hole is based on the premise that convergent evolution has made the active sites of these unrelated enzymes functionally identical.