Ozone reacts with the carbon-carbon double bonds of unsaturated fatty acids from vegetable oils giving rise to the formation of chemical species, such as ozonides and peroxides that are responsible for the germicidal action, as well as the properties of stimulating tissue repair and regeneration [11, 12].
This paper presents a bibliographic review on ozonized oils, synthesis of ozonides, physico-chemical characterization, therapeutic properties and antimicrobial activity.
The reaction of the ozone with unsaturated fatty acids from vegetable oils generates ozonides, peroxides and aldehydes .
Ozonides (5), dimeric (6) or polymeric peroxides may be by-products.
Microwave Spectrum, Molecular Structure and Dipole Moment of the Primary Ozonide
This could be explained based on the fact of presence of many oxygenated compounds other than ozonides that have been generated during the ozonization process of the oil such as hydroperoxides and aldehydes; this might contribute to the increased TBARS content in rat colonic mucosa.
Hernandez, "Spectroscopic characterization of ozonides with biological activity," Ozone: Science & Engineering, vol.
Human sensitivity to complex mixtures of short- and long-lived radicals, ozonides, organic adds, and other oxygenated intermediates species remains unknown.
Given that eNO is a marker of oxidative stress, exposures to certain products of indoor chemistry (e.g., OH radicals, N[O.sub.3] radicals, ozonides, and hydroperoxides) may also lead to increases in eNO.
Reactions of alkenes with ozone in the gas phase: a matrix-isolation study of secondary ozonides
and carbonyl-containing reaction products.
These authors suggested that oxidation intermediates (ozonides
, hydroxy-hydroperoxides) might be involved in the inflammatory process.