para-aminosalicylic acid

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Related to P-aminosalicylic acid: Sodium aminosalicylate

para-aminosalicylic acid

[¦par·ə ə¦me·nō¦sal·ə¦sil·ik ′as·əd]
(pharmacology)
C7H7NO3 White, crystalline drug used with other drugs in the treatment of tuberculosis. Abbreviated PAS.
References in periodicals archive ?
Of 50 MDR-TB isolates, 18 (18/50, 36%) showed resistance to ethionamide (ET), 13 (13/50, 26%) to d-cycloserine (DC), 11 (11/50, 22%) to ciprofloxacin (CP), 7 (7/50, 14%) to kanamycin (KA), 6 (6/50, 12%) to p-aminosalicylic acid (PA), and 5 (5/50, 10%) to amikacin (AM).
Phenotypic testing of isolates showed that arylsulfatase activity was positive at day 3 (weakly positive in 1 isolate); p-aminosalicylic acid degradation was positive, but the organism was also tolerant to 5% sodium chloride (results uncertain for 1 isolate); and iron uptake was positive, all of which are suggestive of Mycobacterium abscessus.
According to the standard XDR TB regimen used in this province, patients were receiving [less than or equal to] 3 active drugs (pyrazinamide, p-aminosalicylic acid, and cycloserine), which increases the risk for treatment failure and further amplification of drug resistance.