Cymene

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cymene

[′sī‚mēn]
(organic chemistry)
Any of the isomeric hydrocarbons metacymene, paracymene, and orthocymene; paracymene is a liquid that is colorless, has a pleasant odor, and is made from oil of cumin or oil of wild thyme.

Cymene

 

(also methyl-isopropyl-benzene), an aromatic hydrocarbon having the structural formula

The meta-, ortho-, and para-isomers of cymene are known; the most important is para-cymene, which is a component of turpentine and many essential oils, including cumin oil and eucalyptus oil. A colorless liquid with a characteristic odor, para-cymene has a boiling point of 177.1°C, a melting point of –67.9°C, and a density of 0.857 g/cm3 at 20°C. Cymene is insoluble in water, but it is miscible with many organic solvents.

The similarity of the carbon skeleton of para-cymene with the skeletons of many cyclic terpenes is a result of their common origin. Thus, para-cymene may be produced by the pyrolysis of α-pinene, the dehydrogenation of limonene, or the heating of camphor with P2O5. In the chemical industry, para-cymene is produced from sulfite turpentine and is used as a raw material and a solvent.

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Furthermore, the significance of the phenolic ring was demonstrated by the lack of activity of the monoterpene cyclic hydrocarbon p-cymene.
Moreover, the plants treated with salicylic acid led to increase in cumin aldehyde and [beta]-terpinene, p-cymene and [beta]-pinene.
In the present work, we used p-cymene/[beta]-cyclodextrin ([beta]-CD) complex and p-cymene isolated to evaluate in nociceptive and inflammatory animal protocols, and study whether the complex formulation is able to improve the pharmacological activity of this monoterpene.
On the other hand, its constituents thymol, p-cymene, [gamma]-terpinene and myrcene are considered weak cytotoxic agents.
Tween 80, Indomethacin, [lambda]-Carrageenan, p-Cymene (99% purity) and [beta]-cyclodextrin ([greater than or equal to] 97% purity) were purchased from Sigma-Aldrich (USA).
In contrast, the highest [gamma]-terpinene and p-cymene contents as precursors of carvacrol and thymol were observed in post-flowering and full-flowering and and the lowest in pre-flowering stage, but not significant differences are there in the total amount of the main components in different ontogenesis condition (Table, 3).
Deuterium/hydrogen ratio analysis of thymol, carvacrol, [gamma]-terpinene and p-cymene in thyme, savory and oregano essential oils by gas chromatography-pyrolysis-isotope ratio mass spectrometry.
This study shows that the Origanum majorana, is the main source for trans sabinene hydrate, Terpinene-4-ol and other valuable components such as [delta]-terpinene, p-cymene, sabinene, [alpha]-terpineol, [alpha]-phellandrene, and [beta]-caryophyllene.
Compound RI % Flowers % Aerial Mode of oil parts oil Identification p-Cymene 1030 t 0.
They determined that essential oil content were between 4,8-10,8 % and major components were carvacrol (481,9- 489,9 mg/mL), [gamma]-terpinene (40,7- 65,2 mg/mL), p-cymene (40,2- 54,0 mg/mL) from June to July.
Standard thymol pure sample was supplied by Merk and the standard carvacrol and P-cymene pure samples were supplied by Aldrich.