P-selectins are lectin-like adhesion glycoproteins that function as cell adhesion molecules which mediate leukocyte rolling on the surfaces of activated endothelial cells.
angulata whole fruit (WF) juice administered at 0.5, 1.0, and 1.5 ml/kg/day on 11 serum inflammatory biomarkers (cytokines) of atherosclerosis such as interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-18 (IL-18), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), C-reactive protein (CRP), tumor necrosis factor-[alpha] (TNF-[alpha]), and P-selectin in rabbits fed high-cholesterol diet.
Schumacher, "E-/ P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung," British Journal of Cancer, vol.
P-selectin is a molecule which belongs to the selectin family together with P-platelets, E-endothelials, and L-leukocytes.
These ECs support leukocyte rolling under non-inflamed conditions, (31) due to a constitutive, low-level expression of E- and P-selectins
. The rolling frequency is largely determined by P-selectin
, with E-selectin playing a smaller role, and L-selectin is not involved.
On the other hand, ENA78/CXCL5, ITAC/CXCL11s, soluble VCAM-1 (sVCAM), soluble ICAM-1 (sICAM-1), and E- and P-selectins were determined using the Versa[MAP[TM] human custom multi-analyte profiling development system (R&D Systems, Abingdon, UK) which is also based on multiplex assays designed to measure analytes in plasma matrices.
Thus, monocyte/macrophage accumulation at the lesion site is a key factor in atherosclerotic disease and involves several steps including monocyte recruitment by increased levels of adhesion molecules (sVCAM, sICAM, E-, and P-selectins) and chemotactic factors (MCP-1, MIP-1[beta], IP-10, and RANTES), the induction of activation, differentiation, and proliferation processes, and immobilization of macrophages in the inflamed plaque .
Esko, "Heparin's antiinflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins," Journal of Clinical Investigation, vol.
Thus, the term PSGL-1 is misleading because of two reasons: (i) the mucin is not a glycoprotein ligand for P-selectin only but the major ligand for all three selectins and (ii) although it is true that there are several selectin binding proteins, the numbering of PSGL became obsolete as other selectin ligands are structurally different proteins.
Stoolman, "E- and P-selectins
are essential for the development of cockroach allergen-induced airway responses," Journal of Immunology, vol.
make the artery walls sticky enough that the white blood cells will attach when they are in the affected areas.
Expression induction of vascular selectins (E- and P-selectins
) allows recruitment of some immunological cells to inflammatory sites .