The biologic effects of HOXB6 were seen to be largely dependent on DNA binding but they were independent of direct interaction of PBX1
FISH analysis using dual color probes for the PBX1
gene at 1q23.3 and TCF3 gene at 19p13.3 detected three copies of 1q in 32% of bone marrow cells.
Several partners of EWSR1 are described: POU5F1 (6p21.33) (16%), PBX1
(16%), PBX3, ZNF444, ATF1, KLF17, and NFATC2 [10-16].
Uterine congenital anomalies have a heterogeneous genetic basis, with implications of Wilms tumour 1 gene (WT1), paired box gene 2 (Pax2), WNT2, pre-B-cell leukemia transcription factor 1 (PBX1
), and homeobox (HOX) genes .
EWSR1 rearrangements are also seen in a variety of epithelial and soft tissue tumors, including soft tissue myoepithelioma; however, the partner genes that are common in myoepithelioma (FUS, POU5F1, PBX1
, and ZNF444) have not been shown to be involved in HCCC.
In addition, KLF4, a member of the KLF family, increased transcriptional activity of the Nanog promoter in cooperation with Oct4 and Sox2 (Wei et al., 2009) or with a homeodomain transcription factor PBX1
in human ESC (Chan et al., 2009).