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Its main angiogenesis is realized by the action of fibroblast growth factor, VEGF, and PDGF, which are soluble factors in the fibrin gel (49).
Major signaling pathways and effectors in liver fibrosis Pathway Effectors Growth factor signaling PDGF, TGF-[alpha], EGF, VEGF Fibrogenic signaling pathway TGF-[beta]1 Chemokine pathways CCR5, CCR1, CXCL4, CXCL9, CXCR3 Adipokine pathways Leptin, adiponectin Neuroendocrine pathways Cannabinoid and opioid signaling, thyroid hormones, serotonin CCR: C-C chemokine receptor; CXCL: CXC chemokine ligand; CXCR: CXC chemokine receptor; EGF: epidermal growth factor; PDGF: platelet-derived growth factor; TGF: transforming growth factor; VEGF: vascular endothelial growth factor
The Role of HMGB1-RAGE Signaling in PM2.5-Induced TGF-[beta]1 and PDGF Production in HBECs.
FGF1 expression in oral mucosa scars had similar positivity as PDGF BB: positive 2+ in all cases in endothelial cells, positive 1+ in macrophages, and negative in mesenchymal cells (Figures 4(n)-4(o)).
PDGF induces partial EMT in vivo and stimulates human PMC proliferation through increased PDGF/ERK signaling.
(2009) Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia.
[120.] DT Cromack, GF Pierce, TA Mustoe, TGF-beta and PDGF mediated tissue repair: identifying mechanisms of action using impaired and normal models of wound healing, Prog Clin Biol Res, 365, 359-373, (1991).
The CGF can be considered as the new generation of fibrin matrices blocks with a high concentration in growth factors, including platelet-derived growth factor (PDGF), transforming growth factor b (TGF-b), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) (Rodella et al.).
Subsequently, the PVDF membranes were probed with primary antibodies against NOS2 (1: 1000, CST, US), CD206 (1: 1000, CST, US), TNF-[alpha] (1: 1000, CST, US), and PDGF (1: 1000, Santa Cruz, CA, USA) at 4[degrees]C overnight.
PDGF and TGF-[beta] are the wound healing substances that have shown to play an important role in the healing of bone.
Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), pigment epithelium -derived factor (PEDF), P62, and antiangiostatin monoclonal antibodies were purchased from Abcam (Cambridge, UK).
Hemostasis begins immediately after the injury and involves vascular constriction and aggregation of platelets to form a fibrin clot, from where proinflammatory cytokines and growth factors such as transforming growth factor, epidermal growth factor, fibroblast growth factor, and platelet-derived growth factor (PDGF) are released .
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- PDGF A-chain
- PDGF receptor
- PDGF subunit A
- PDGF subunit B
- PDGF, B chain
- PDGFA-Associated Protein 1