PEO

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PEO

(Professional Employer Organization) A company that serves as an off-site human resources department to small and medium-sized organizations. A fast-growing business segment after the new millennium, PEOs are relationship-focused and take responsibility for HR administration plus legal and regulatory compliance issues. The quality of employee benefits in areas of insurance and workers compensation is often improved due to the expertise and group purchasing power of a PEO.
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References in periodicals archive ?
Similar to POLG, mutations in other nuclear genes, like twinkle, a mtDNA helicase required for mtDNA replication and stability, lead to accumulation of mtDNA deletions and have been found to be associated with parkinsonism [68-70].
Minor patients with two mutations in POLG , DGUOK , TK2 , and SUCLA2 genes showed a wide phenotypic spectrum, including Alpers' syndrome, early-onset hepatocerebral disease, myopathy, and ophthalmoparesis.
Sample type Findings Potential utility CRC tissues (n = 50) There was no Risk evaluation and the association between corresponding the CAG repeat noncancerous variants in the POLG tissues.
Primers and probes used for allelic discrimination real-time PCR of the R964C and E1143G polymorphisms of POLG SNP C-2890T Forward Reverse Sense-wild Sense-mutant A-3428G Forward Reverse Antisense-wild Antisense-mutant Sequence PCR product size Primer 5 '-GCCAAAATCTTCAACTACG-3' 5 '-TGGGTGTTAAAGTGGATG-3' 180 Probe CAGCCCTTTGCTGAG(C)GCTTACTAAT CAGCCCTTTGCTGAG(T)GCTTACTAAT Primer 5 '-TGGCTGTTTGAAGAGTTTG-3' 5 '-CGCATACCTGGTCAAGAG-3' 138 Probe CGGTCCTCC(T)CCCGCACCAG CGGTCCTCC(C)CCCGCACCAG Red font is used to emphasise the change in the sequence.
Apart from the trading update, the newly formed Polyus Gold International (POLG LI - Not rated) elected a new board of directors.
We also analyzed 165 samples from patients with molecularly proven MDDS (i.e., 2 deleterious mutations): 122 blood, 21 muscle, 15 liver, and 7 skin fibroblast samples from patients with 2 proven mutations in 1 of 8 nuclear genes (POLG, DGUOK, TK2, TYMP, MPV17, SUCLA2, SUCLG1, and RRM2B) known to cause mtDNA depletion.
Copeland's research has helped to identify approximately 200 POLG mutations in disease.
The minimal proteins required for mtDNA transcription (e.g., POLRMT and mitochondrial transcription factor B (mtTFB)) and replication (POLG and POLG2) are embedded in the core region of nucleoids through their mtDNA-binding capabilities [13, 43, 62].
Human pol [gamma]A is a 140 kDa polypeptide with 1239 amino acids, (18) encoded by POLG (GenBank Accession AF497906.1 [or NG_008218.1]) in band 15q25.
Another subgroup of patients showed normal or near-normal oxygen consumption rates in fibroblasts that may be a reflection of a tissue-specific mitochondriopathy, which is not uncommon, e.g., mtDNA mutations with uneven tissue distribution or POLG [polymerase (DNA directed), [gamma], formerly POLG1] gene mutations.
The enzymes important for mtDNA repair, that is, 8-oxoguanine DNA glycosylase (OGG1), MutY homolog, and thymine DNA glycosylase, become subnormal, and the transcription and replication mechanisms including mitochondrial transcription factor A (TFAM) and polymerase gamma (POLG) are also compromised [156,157].