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A thorough characterization of PRNP variation in a U.
High throughput is achieved by use of the LightCycler only for the diagnostic melting, whereas the specific PRNP PCR is done in a conventional thermocycler at lower cost.
Tissues analyzed were obtained from 2 patients who originated from the United Kingdom: 1 patient had the PRNP codon 129VV genotype (patient UK-VV), and the other had the 129MV genotype (patient UK-MV).
C] of the PRNP codon 129 methionine (129MM) and valine (129VV) genotypes (11-13) were used for PMCA substrate preparation.
We describe a rapid and accurate method for the genotyping of the PRNP codon 129 polymorphism based on real-time PCR mutation detection by melting-point analysis with fluorescent hybridization probes with fluorescence resonance energy transfer (3,4).
The most important genetic risk factor for development of vCJD is homozygosity for methionine on PRNP codon 129, and all but 1 patient with clinical vCJD carry this polymorphism (5).
All animals were homozygous for M at codon 129 of the PRNP gene (4,22).
The methionine (M)/valine polymorphism at codon 129 of the PRNP gene has been examined in populations with and without CJD in many countries; results have varied (Table 3).
Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk.
Sequencing of the open reading frame of the PRNP gene of cow 2 (which was unsuccessful for cow 1) indicated that the encoded protein was identical to the common bovine PrP amino acid sequence (as translated from GenBank accession no.
High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age.
The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep.