cardiac pacemaker

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cardiac pacemaker

[′kärd·ē‚ak ′pā‚smā·kər]
(medicine)
References in periodicals archive ?
The researchers, employing a virus engineered to carry a single gene (Tbx18) that plays a key role in embryonic pacemaker cell development, directly reprogrammed heart muscle cells (cardiomyocytes) to specialized pacemaker cells.
Previous efforts to generate new pacemaker cells resulted in heart muscle cells that could beat on their own.
Abnormalities of enteric neurons, intestinal pacemaker cells, and smooth muscle in human intestinal atresia.
The results of this study suggest that GISTs originate from CD34-positive stem cells, which differentiate to express the pacemaker cell phenotype.
Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal.
Evidence from the diabetic mice suggested that the excess deaths following heart attack was due to heart rhythm abnormalities, prompting the team to investigate the heart's pacemaker cells, which control heart rate.
Looking at the diabetic mice, the team found that pacemaker cells had elevated levels of oxidized CaMKII enzyme and more cell death than pacemaker cells in non-diabetic mice.
Strogatz first came across Peskin's work on synchronized electrical signals among pacemaker cells while thumbing through a book by Winfree on the geometry of biological time.
Although we and others have created primitive biological pacemakers before, this study is the first to show that a single gene can direct the conversion of heart muscle cells to genuine pacemaker cells.
The heartbeat originates in the sinoatrial node (SAN) of the heart's right upper chamber, where pacemaker cells are clustered.
But the Cedars-Sinai researchers, employing a virus engineered to carry a single gene (Tbx18) that plays a key role in embryonic pacemaker cell development, directly reprogrammed heart muscle cells (cardiomyocytes) to specialized pacemaker cells.
The new work, with astonishing simplicity, creates pacemaker cells that closely resemble the native ones free from the risk of cancer.