Paget's disease


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Paget's disease

[′paj·əts di‚zēz]
(medicine)
A type of carcinoma of the breast that involves the nipple or areola and the larger ducts, characterized by the presence of Paget's cells.
Osseous hyperplasia simultaneous with accelerated deossification.
An apocrine gland skin cancer, composed principally of Paget's cells.
References in periodicals archive ?
Cancers of the Anal Margin and Anal Canal, Bowen's Disease, and Paget's Disease. Operative Techniques in General Surgery 2001;3:171-182.
A new entity with histogenetic implications for cutaneous Paget's disease," American Journal of Surgical Pathology, vol.
Paget's disease of the nipple with parenchymal ductal carcinoma in situ is associated with worse prognosis than Paget's disease alone.
Osteitis deformans (Paget's disease of the bone) was first described as a chronic inflammation of the bone by Sir James Paget in 1877.[sup][1] Literature regarding its etiology primarily associates the disease to viral antigens, chromosomal translocations, and environmental factors but lacks substantial evidence.[sup][1],[2] Pathogenesis of the disease is characterized by accelerated osteoclastic activity followed by ineffective and chaotic osteoblastic activity resulting in a poorly mineralized and deformed bone that is highly vascular.[sup][3] Presentation of the disease is frequently polyostotic and rarely monostotic.
Flanagan, "Mammary and extramammary Paget's disease," Journal of Clinical Pathology, vol.
Ralston, "Biology and treatment of Paget's disease of bone," Journal of Cellular Biochemistry, vol.
Matsunaga, "Mammary and extramammary Paget's disease," Anais Brasileiros de Dermatologia, vol.
Paget's disease of the bone is a chronic disorder characterized by excessive bone formation and disorganized remodeling.
Miacalcic is a well-known international orthopedic salmon-calcitonin brand with the recognition from global medical professionals for the treatment of osteoporosis, prevention of postmenopausal osteoporosis, treatment and prevention of glucocorticoid-induced osteoporosis, prevention of clinical fractures after hip fracture, and treatment of Paget's disease of bone.
Paget's disease starts with the purposeless proliferation of osteoclasts that destroy bone, thus releasing minerals from the collagenous matrix.
Osteoporosis, Paget's disease, and osteogenesis imperfecta are some of the common bone diseases.
Because Charcot joint or Paget's disease was suspected, laboratories and a skeletal survey were ordered.