islets of Langerhans

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islets of Langerhans:

see pancreaspancreas
, glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system).
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Islets of Langerhans


the groups of cells in the pancreas of man and vertebrates (except cyclostomes) that form the endocrine part of the organ, secreting the hormones insulin and glucagon into the blood.

The islets of Langerhans are named for the German scientist P. Langerhans, who described them in 1869. In 1901, the Russian scientist L. V. Sobolev proved their endocrine function and established the occurrence of changes in the islets with diabetes mellitus. The dimensions of the islets of Langerhans are 50 to 500 microns, and there are between ten and 20 islets per mg of gland tissue. The islets do not communicate with the gland’s effluent ducts.

The islets of Langerhans develop from tubular processes of the anterior gut and, depending on the type of animal, consist of cells of several types. All animals have α cells and β cells. The granules of α cells are considered to be a form of glucagon deposit; the β cells, of insulin. C cells and D cells (the former have been found in the islets of Langerhans of guinea pigs; the latter, in man and dogs), which lack granules, are converted to α cells and β cells. In all, the tissue of the islets of Langerhans makes up 0.9 to 3.6 percent of the mass of the pancreas in children and 0.9 to 2.7 percent in adults.


References in periodicals archive ?
1st pancreatic islet transplant from brain-dead donor conducted
A team of Japanese researchers has succeeded in generating a pancreatic islet for controlling blood sugar levels using induced pluripotent stem cells, known as iPS cells, they said Sunday.
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Pancreatic islet transplantation is a promising treatment for diabetes but still faces several challenges.
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We conclude that the absence of clinically evident hormonal activity should not dissuade the physician from considering the possibility of a pancreatic islet cell primary tumor when a patient presents with metastatic neuroendocrine malignancy, even when there is no clear radiographic evidence of a pancreatic mass.
Reparixin is the investigational drug developed by Dompe to improve efficacy of the experimental pancreatic islet transplantation procedure
As part of this arrangement, PCT will perform microencapsulation for parsing beta pancreatic islets for xenotransplantation using piglet pancreata.
It is located in the pancreatic islets, clusters of cells that secrete the hormones insulin and glucagon that work together to regulate blood sugar.
Novocell encapsulation technology uniformly coats donated pancreatic islets with a thin layer of biocompatible material.
To test the hypothesis, they examined freshly isolated mouse pancreatic islets and subjected samples to physiological assays.