Paneth cells

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Paneth cells

[′pan·əth ‚selz]
(histology)
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Paneth cell granule depletion in the human small intestine under infective and nutritional stress.
The work of Ouellette and his colleagues "is a successful culmination of efforts to understand Paneth cell function," comments Tomas Ganz of the University of California, Los Angeles in the same journal.
reported the significant role of Paneth cell derived IL-17A in the aggravation of the observed systemic inflammatory syndrome and the exacerbation of renal injury [29].
Wang et al., "Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats," PLoS One, vol.
For example, Wnt signals in vivo are produced by the subepithelial mesenchyme and Paneth cell and thus restricted to the bottom of the crypts where they are crucial for maintaining ISCs in a self-renewing state [92].
Phloxine-Tartrazine stains for Paneth cell granules.
The clinical significance of this role has been well documented for Crohn's disease, which is characterized by Paneth cell dysfunction with reduced HD5 production, alteration of the resident microbiota, subsequent inflammation, and T cell-mediated immune responses [49].
C, Paneth cell metaplasia (arrow) and unevenly spaced crypts in the left colon.
Prince et al., "Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice," Disease Models & Mechanisms, vol.
XBP1 is important for the development of secretory cells and mice lacking XBP1 exhibit Paneth cell dysfunction and associated intestinal inflammation [70].
Ouellette, "a-defensins in enteric innate immunity: functional paneth cell a-defensins in mouse colonic lumen," Journal of Biological Chemistry, vol.
Sustained TL1A expression in T cells or dendritic cells promotes goblet cell and Paneth cell hyperplasia in the small intestine in mice [26, 27, 34].