Histamine H2 antagonist drugs block the H2 receptor on the parietal cell
 The muscularis mucosa is still visible and quite intact, but its surface is starting to erode, the adipose tissues are starting to invade, the chief cells are degrading, and the parietal cells
are redilating due to necrosis.
In general, expression of all mitochondrial markers was significantly lower in chief cells than in epithelial and parietal cells
(Figure 7), as expected.
Mardh, "Major parietal cell
antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+, K+-adenosine triphosphatase of the stomach," The Journal of Clinical Investigation, vol.
All PPIs are substituted derivatives of benzimidazole, which is pharmaceutically inactive compound with short half-life of (0.6 - 1.9 hours), needs acidic environment of the secretory canaliculus of the stimulated parietal cells
, with a pH of approximately 1.0.
These cells divide periclinally to form a primary parietal cell
to the outside and a primary sporogenous cell to the inside (Fig.
Figure 3 shows that both parietal cells
and enteroendocrine like glandular cells displayed strong GLP-1R immunoreactivity.
PA is macrocytic anemia due to vitamin B12 deficiency as a result of deficiency of intrinsic factor because of the atrophy of gastric mucosa and thus the loss of parietal cells
.9 Varying incidence rates of PA have been reported.1011
The parietal cells
were brighter with central nuclei and appeared distinct from the chief cells.
Through experiments conducted in mice, the researchers found that podocytes cannot be renewed from parietal cells
. In fact, after the loss of podocytes, parietal cells
play a negative role by causing kidney scarring that contributes to progressive kidney function decline.
In the 1970s, evidence emerged that the proton pump in stomach parietal cells
was the last step in acid secretion.
Gastric parietal cells
of the ectopic gastric mucosa have been shown to produce pathophysiologic levels of acid, which can lead to the above-mentioned symptoms.