Parkinson's disease

(redirected from Parkinsons)
Also found in: Dictionary, Thesaurus, Medical.

Parkinson's disease



degenerative brain disorder first described by the English surgeon James Parkinson in 1817. When there is no known cause, the disease usually appears after age 40 and is referred to as Parkinson's disease; a number of genes have been found to be associated with the disease. Parkinsonism usually refers to similar symptoms resulting from head injury, encephalitis, syphilis, carbon monoxide poisoning, cerebral arteriosclerosis, or use of MPTP (a synthetic narcotic). The disorder is also termed paralysis agitans, or shaking palsy.

Parkinson's disease is a debilitating and progressive disorder in which the chemicals that facilitate electrical transmission between nerve cells are depleted. It was the first disease to be treated by drugs that replace deficient neurotransmittersneurotransmitter,
chemical that transmits information across the junction (synapse) that separates one nerve cell (neuron) from another nerve cell or a muscle. Neurotransmitters are stored in the nerve cell's bulbous end (axon).
..... Click the link for more information.
. Symptoms usually begin in middle to later life with trembling of the lips and hands, loss of facial expression, and muscular rigidity. As it progresses it may bring on body tremors, particularly in muscles at rest. Movements become slow and difficult; walking degrades to a shuffle. After many years physical incapacity may occur. Dementia occurs in at least 50% of the patients; depression is also common.

When drugs such as levodopa (L-Dopa) are taken orally, many of the worst symptoms are lessened. New drugs such as pramipexole (Mirapex) and ropinirole (Requip) can delay the need for levodopa. Apomorphine (Apokyn) is used treat episodes of reduced mobility in patients with advanced Parkinson's that responds less effectively to levodopa. Future approaches to treatment include a focus on early detection and slowing progression of the disease. Encouraging results have been reported from surgical insertion of a pacemakerlike device deep in the brain to suppress uncontrolled movements, but surgical transplantation of fetal dopamine-producing cells failed to show significant benefits in a controlled study. Traditional surgery can alleviate some tremors, and physical therapy may help mobility.

The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.

Parkinson's disease

[′pär·kən·sənz di‚zēz]
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
[ClickPress, Mon Jun 03 2019] The Parkinson's disease treatment market growth was driven because of increase in the geriatric population and the rise in the occurrence of the Parkinson's disease and the funding for research.
Host gathering for Parkinson's research WHATEVER the weather and wherever you are, why not gather with friends and family this summer and help raise vital funds that will help cure and support everyone affected by Parkinson's.
SOUTH Wales residents are being encouraged to lace up their trainers and help stop Parkinson's in its tracks by running the Cardiff Half Marathon in support of Parkinson's UK.
This turn of events started a chain reaction of transience for the Parkinsons. They spent a few months in Miami stocking up on supplies and waiting for the elder Parkinson to be re-assigned.
IT'S Parkinson's Awareness Week and a campaign has been launched to remind people about the importance of getting their medication on time.
The Chester Walk for Parkinson's event is one of 45 across the UK set to raise more than [pounds sterling]600,000 for charity Parkinson's UK's pioneering research to find better treatments and a cure for the condition.
The Parkinson's Power project aims to help people with the condition improve their physical and mental health.
Here, Katie Goates, of Parkinson's UK, explains just 10 potential symptoms ...
The Ludlow Walk for Parkinson's event is one of 45 across the UK set to raise over PS600,000 for charity Parkinson's UK's pioneering research to find better treatments and a cure for the condition.
For more than half a century, we've made tangible progress on all fronts, from the largest clinical study of Parkinson's ever, which has significantly improved care, to breakthrough treatments.
Parkinson's UK service manager, Louise Buchanan said:"Our experience of running these groups over the last two years is that people really value the chance to meet others and talk through some of the bigger questions about life with Parkinson's.