agonist

(redirected from Partial agonism)
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agonist

[′ag·ə‚nist]
(biochemistry)
A chemical substance that can combine with a cell receptor and cause a reaction or create an active site.
(physiology)
A contracting muscle that is resisted or counteracted by another muscle, called an antagonist, with which it is paired.
References in periodicals archive ?
ACP-104 combines M1 muscarinic agonism, 5-HT2A inverse agonism, and dopamine D2 and D3 partial agonism in a single compound and, therefore, uniquely addresses what ACADIA believes are the three most promising target mechanisms for treating schizophrenia.
In addition, the combined antagonism at 5-HT2A and partial agonism at D2 receptors in vivo suggests ACP-104 may produce antipsychotic activity with reduced extrapyramidal side effects.
By combining D2 and D3 dopamine partial agonism, M1 muscarinic agonism, and 5-HT2A inverse agonism in a single molecule, ACP-104 uniquely addresses the three most promising target mechanisms for treating psychosis," said Mark R.