agonist

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Related to Partial agonist: therapeutic index, Inverse agonist

agonist

[′ag·ə‚nist]
(biochemistry)
A chemical substance that can combine with a cell receptor and cause a reaction or create an active site.
(physiology)
A contracting muscle that is resisted or counteracted by another muscle, called an antagonist, with which it is paired.
References in periodicals archive ?
A full agonist (2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,3,7,8-tetrachlorodibenzofuran) was combined with either a full agonist (3,3',4,4',5-penta-chlorobiphenyl), a partial agonist (2,3,3', 4,4'-pentachlorobiphenyl or galangin), or an antagonist (3,3-diindolylmethane).
Because of the partial agonist effect, buprenorphine could result in less physical dependence and less withdrawal symptoms
As a dopamine D3-preferring D3/D2 partial agonist, cariprazine offers an alternative to antipsychotics that preferentially modulate D2 receptors.
It is actually buprenorphine acting as a partial agonist that precipitates withdrawal in opiate dependent persons.
(1-6) Although brexpiprazole is a dopamine D2 partial agonist, it differs from aripiprazole, the other available D2 partial agonist, because it is more potent at serotonin 5-HT1A and 5-HT2A receptors and displays less intrinsic activity at D2 receptors, (7) which could mean better tolerability.
Buprenorphine is a mu-opioid receptor partial agonist and a potent analgesic with a relatively long duration of action.
DCS, an NMDA (N-methyl-D-aspartate)-receptor partial agonist approved as an antibacterial by the Food and Drug Administration, enhances exposure therapy for conditions that include social anxiety and acrophobia in previous studies.
It is the first dopamine D2 partial agonist to be approved in Europe as a once-monthly vaccine and will cater to the need for relapse prevention among patients of the psychological disorder, with clinical study data supporting its safety and effectiveness.
Buprenorphine is a partial mu-opioid agonist, an antagonist at the kappa-opioid receptor, and a partial agonist at the ORLl/nociceptin and delta-opioid receptors.
SAN ANTONIO -- The discovery that the angiotensin II receptor blocker telmisartan also acts as a partial agonist of peroxisome proliferator-activated receptor-[gamma] makes it a uniquely promising candidate for the treatment of metabolic syndrome and prevention of type 2 diabetes and cardiovascular disease, Dr.
Buprenorphine is a Schedule III controlled substance and is a mu-opioid receptor partial agonist and a potent analgesic with a relatively long duration of action.