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A variety of infectious diseases caused by the coccobacilli Pasteurella multocida and P. haemolytica; the term also applies to diseases caused by any Pasteurella species. All Pasteurella species occur as commensals in the upper respiratory and alimentary tracts of their various hosts. Although varieties of some species cause primary disease, many of the infections are secondary to other infections or result from various environmental stresses. Pasteurella species are generally extracellular parasites that elicit mainly a humoral immune response. Several virulence factors have been identified. See Virulence

Pasteurella multocida is the most prevalent species of the genus causing a wide variety of infections in many domestic and wild animals, and humans. It is a primary or, more frequently, a secondary pathogen of cattle, swine, sheep, goats, and other animals. As a secondary invader, it is often involved in pneumonic pasteurellosis of cattle (shipping fever) and in enzootic or mycoplasmal pneumonia of swine. It is responsible for a variety of sporadic infections in many animals, including abortion, encephalitis, and meningitis. It produces severe mastitis in cattle and sheep, and toxin-producing strains are involved in atrophic rhinitis, an economically important disease of swine. Hemorrhagic septicemia, caused by capsular type B strains, has been reported in elk and deer in the United States.

All strains of P. haemolytica produce a soluble cytotoxin (leukotoxin) that kills various leukocytes of ruminants, thus lowering the primary pulmonary defense. It is the principal cause of the widespread pneumonic pasteurellosis of cattle. Other important diseases caused by certain serotypes of P. haemolytica are mastitis of ewes and septicemia of lambs.

All of the Pasteurella species can be isolated by culturing appropriate clinical specimens on blood agar. Multiple drug resistance is frequently encountered. Treatment is effective if initiated early. Among the drugs used are penicillin and streptomycin, tetracyclines, chloramphenicol, sulphonamides, and some cephalosporins. Sound sanitary practices and segregation of affected animals may help limit the spread of the major pasteurelloses. Live vaccines and bacterins (killed bacteria) are used for the prevention of some. See Pasteurella



(also hemorrhagic septicemia), an infectious disease of animals and man characterized by septicemia, inflammation of the mucous membranes of the respiratory and intestinal tracts, pneumonia, and edema. The causative agents are bacteria of the genus Pasteurella, and the source of these agents is infected animals or animals that have recovered from the disease. Lowered resistance owing to unfavorable environmental factors is important in the origin of the disease. Infection occurs by airborne transmission or by ingestion of the bacteria.

The symptoms of pasteurellosis in animals include elevated temperature, anorexia, severe prostration, and accelerated pulse and respiratory rates. When the respiratory organs are primarily involved, the animals exhibit a mucopurulent discharge from the nose, conjunctivitis, labored breathing, and coughing. The intestinal form is manifested by severe diarrhea, weakness, and, in the case of cattle, sheep, goats, and swine, edema of the head, neck, dewlap, and elsewhere. If the course of the disease is superacute, the animals die quickly with no visible symptoms.

Diagnosis is based on clinical symptoms, epizootiological data, and results of bacteriological tests. Treatment involves the administration of specific hyperimmune serum, antibiotics, and sulfanilamides. It is not considered worthwhile to treat infected poultry. Prevention includes proper housing and feeding of animals and observation of sanitary veterinary measures. Vaccines are used for active prevention.

Pasteurellosis of man is characterized by local lesions in the form of abscesses and phlegmons. In some cases, osteomyelitis or bronchopneumonia may develop. Prevention of the disease in man involves taking proper precautions when handling diseased animals.


Epizoologiia. Edited by R. F. Sosov. Moscow, 1974.



(veterinary medicine)
References in periodicals archive ?
A severe systemic infection is the third and least common form of Pasteurellosis.
Role of Mannheimia haemolytica leukotoxin in the pathogenesis of bovine pneumonic pasteurellosis.
Isolation and characterisation of the causative agent of pasteurellosis, Photobacterium damsela subsp, piscicida, from sole.
He warns that the colostrum lambs receive from the ewe shortly after birth only gives them protection for a limited time against pasteurellosis and the clostridial diseases like pulpy kidney, braxy, blackleg and tetanus.
More than 89,000 saiga antelopes died of pasteurellosis in three regions of Kazakhstan, mass die-off of saiga in Aktobe region stopped, reports the Ministry of Agriculture of Kazakhstan.
The disease can have a variety of causes, but many outbreaks are caused pasteurellosis.
The pigs were vaccinated against hog cholera and Pasteurellosis, and de -wormed 2 weeks before starting the experiment.
The preliminary cause of die-off is pasteurellosis.
Animals were routinely drenched for fluke and roundworm, and vaccinated for pasteurellosis and clostridia infections.
multocida, were identified in some animals, these were not consistently present, and the disease lesions and presentation were not typical of pasteurellosis.
The preliminary cause of mortality is pasteurellosis.
All animals were treated for internal parasites and liver fluke with Bioxinil (Bio Pharmachemie, Ho Chi Minh) and vaccinated for pasteurellosis with P15 vaccine (NaVetCo, Ho Chi Minh City) prior to the experiments.