Paul Greengard


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Greengard, Paul,

1925–2019, American neuroscientist, b. New York City, Ph.D. Johns Hopkins, 1953. Greengard was on the staff at Geigy Research Laboratories (1959–67) and a professor at the Albert Einstein College of Medicine (1961–70) and Yale (1968–83). In 1983 he became a professor at Rockefeller Univ., where he was director of the Fisher Center for Alzheimer's Disease Research from 1995. Greengard shared the 2000 Nobel Prize in Physiology or Medicine with Arvid CarlssonCarlsson, Arvid,
1923–2018, Swedish pharmacologist, grad. Univ. of Lund, Sweden, (M.D., Ph.D., 1951). Carlsson was a professor at the Univ. of Lund (1951–59) and at the Univ. of Gothenburg, Sweden (1959–89).
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 and Eric KandelKandel, Eric Richard,
1929–, American neurobiologist, b., Vienna, Austria, M.D. New York Univ., 1956. Kandel was at the Harvard Medical School (1960–65) and New York Univ. (1965–74) before joining the faculty at Columbia in 1974.
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 for their discoveries concerning signal transduction in the nervous system. Greengard's contribution to the work was his discovery of the mechanism by which dopaminedopamine
, one of the intermediate substances in the biosynthesis of epinephrine and norepinephrine. See catecholamine.
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 and several other neurotransmittersneurotransmitter,
chemical that transmits information across the junction (synapse) that separates one nerve cell (neuron) from another nerve cell or a muscle. Neurotransmitters are stored in the nerve cell's bulbous end (axon).
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 carry messages between nerve cells. His findings contributed to an improved understanding of how several drugs work in the body. He later studied the defects in cell signaling involved in such disorders as Alzheimer's disease and Parkinson's disease.
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References in periodicals archive ?
Lucian Medrihan, a research associate in the lab of neuroscientist and Nobel laureate Paul Greengard who led the study, said: "While existing SSRIs can produce moderate effects within hours or even minutes, most people don't really begin to feel better until they've been on the drugs for a significant amount of time-a major drawback when it comes to treating clinical depression."
Paul Greengard, born in 1925 and a 2000 Nobel laureate in medicine, still works on average six days a week, from 9 A.M.
Paul Greengard of the Rockefeller University in New York led the 2006 study, in which he and his team worked on mice that lacked p11.
To find out if this process is influenced by microRNAs, a team led by Anne Schaefer and Paul Greengard at Rockefeller University offered cocaine to mice whose neurons lack Ago2, a protein essential for the production and function of certain microRNAs.
Paul Greengard and colleagues report in the 10 December 2009 issue of Neuron that improper functioning of the protein complex GLP/G9a is linked in mice to a mental retardation-like effect known as 9q34 syndrome.
Paul Greengard, house families visiting hospitalized military personnel, and convert the scrapped aircraft carrier USS Intrepid into a floating military museum.