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An acute or chronic disease of the skin characterized by the appearance of bullae, which develop in crops or in continuous succession.



a chronic disease characterized by a crop of blisters, or bullae, having a flaccid covering and serous-hemorrhagic contents; the blisters form on the apparently intact skin or mucosa of the oral cavity, larynx, eyes, and genitals. The blisters rapidly enlarge and multiply, bursting to form extensive ulcerated surfaces. The patient’s general condition is disturbed; there is general weakness and elevation of body temperature. Infection of the mouth and larynx makes food intake difficult.

The causes of pemphigus have not been conclusively determined. The disease usually afflicts middle-aged and elderly persons. The mechanism of formation of pemphigus vulgaris is acantholysis, a type of degenerative change in epidermal cells. It involves the dissolution of the intercellular bridges, degenerative change of the nuclei, and loss of part of the cell protoplasm. As a result, communication between the layers of epidermis is disrupted. In other forms of pemphigus, the blisters form as a result of an inflammatory process.

Pemphigus vulgaris progresses gradually, and cachexia develops. The prognosis for persons suffering from other forms of pemphigus is relatively favorable. Treatment includes the ingestion of hormonal preparations, antimicrobial agents, or analgesics. Disinfecting solutions may be applied externally.


References in periodicals archive ?
Chernyavsky Al, Arredondo J, Piser T, Karlsson E, Grando SA: Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis.
Pemphigus, an autoimmune disease that causes blistering of the skin, tends to affect middle-aged and older adults and is more frequent in those of Middle Eastern or Jewish heritage.
4) It thus entails the following differential diagnoses: contact dermatitis, Koebner reaction, lichen striatus, lymphangitis, pemphigus, pemphigoid, porphyria cutanea tarda, staphylococcal impetigo, basal cell carcinoma, vasculitis, sensory nerve lesions, excoriations due to scabies, pediculosis, and eczema.
The pemphigus complex is a rare disease of the skin and mucous membranes.
Pemphigus, however, is a different story and treating this skin disease promptly is absolutely essential as it can make you very ill very quickly.
This aphid, Pemphigus obesinymphae, turned out to be a good species for studying a soldier's life.
Skin diseases such as pemphigus and pemphigoid cause ulcers and are easy for a dentist to refer on.
Sometimes patients with pemphigus may go into remission and have no problems for long periods.
Treatment of pemphigus would certainly be considered medically necessary, based in part on the functional impairment of the skin to maintain fluid balance.
Cyclosporine A, when administered systemically (Sandimmune, Neoral), is an effective treatment for psoriasis, atopic dermatitis, pemphigus vulgaris and other severe inflammatory dermatoses.
The pathology differential diagnosis for lichen planus includes mucous membrane pemphigoid, pemphigus vulgaris, lichenoid reaction to drugs, lupus erythematosus, chronic graft-versus-host disease, linear IgA disease, and cinnamon-induced stomatitis.
Discovery of autoantibodies of pemphigus and bullous pemphigoid by immunofluorescence techniques and first clinical use of corticosteroids are two major milestones in the history of development processes in diagnosis and treatment of autoimmune bullous diseases in early 1960s.