Martin Williams, Vice President of Business Development, Sales and Marketing at Pentose
told MLO "Inactine has killed every virus we've tried."
However, there are a limited number of studies on the expression of pentose
phosphate pathway-related proteins in breast cancer.
Phosphogluconate dehydrogenase (Pgd) is an enzyme that converts 6-phosphogluconate to ribulose 5phosphate in the oxidative branch of the pentose
phosphate pathway, which produces NADPH as well as purine nucleotides .
Pocsi, "Co-ordination of the nitrate and nitrite assimilation, the glutathione and free radical metabolisms, and the pentose
phosphate pathway in Penicillium chrysogenum," Journal of Basic Microbiology, vol.
Yellow color marked pathway is the pentose
phosphate pathway; the number in parenthesis is the gene copy found in the genome; GalK: galactokinase (EC 2.71.6); GalE: UDP-glucose 4-epimerase (EC 220.127.116.11); GalT: UDP-glucose-hexose-1-phosphate uridylyltransferase (EC 18.104.22.168); GalU: UTP-glucose-1- phosphate uridylyltransferase (EC 2.7.79); PGM: phosphoglucomutase (EC 22.214.171.124); XI: xylose isomerase (EC 126.96.36.199); XK: xylulokinase (EC 2.71.17); AI: arabinose isomerase (EC 188.8.131.52); RK: ribulokinase (EC 2.71.16); RI: ribose 5-phosphate isomerase (EC 184.108.40.206); RPE: ribulose-phosphate 3-epimerase (EC 220.127.116.11); TKL: transketolase (EC 18.104.22.168); TAL: transaldolase (EC 22.214.171.124).
However, the main disadvantage of this organism is lacking of mechanisms to take up pentose
sugars as substrate.
The pathway can be considered in two phases: the irreversible oxidative phase comprising the reactions catalyzed by glucose 6-phosphate dehydrogenase, lactonase and 6-phosphogluconate dehydrogenase; and the reversible, non-oxidative phase involving the rest of the pathway, then: Regulation of the pentose
phosphate pathway: The flow of metabolites through the pathway is regulated at the glucose 6-phosphate dehydrogenase reaction and the 6-phosphogluconate dehydrogenase by the availability of NADP +.
The increase in glycolysis activates the enzyme fructose 1, 6 diphosphatase which activates the pentose
phosphate pathway liberating NADPH.
Metabolic network of Corynebacterium glutamicum consists of the EMP pathway, TCA cycle, Pentose
phosphate pathway and gluconeogenesis to represent the central metabolism (Fig.
But the pentose
in the nucleotide might take part in the pentose
phosphate pathway to produce NADPH which could attenuate the damage by free radicals.
Substances stimulating glucose catabolism by the oxidative reactions of the pentose
phosphate pathway in human erythrocytes.
Evidence that the pentose
sugar ribose stimulates ATP synthesis and improves cardiac function led us to test the possibility that ribose increases tolerance to myocardial ischaemia in patients with coronary artery disease (CAD).