Pentylenetetrazol


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Related to Pentylenetetrazol: Metrazol

pentylenetetrazol

[¦pent·əl‚ēn′te·trə‚zȯl]
(pharmacology)
C6H10N4 A central nervous system stimulant used as an analeptic.

Pentylenetetrazol

 

or leptazol, a medicinal preparation that exerts a stimulating effect on the central nervous system and stimulates respiration and blood circulation; in large doses it induces convulsions. It is taken internally (in tablets) or injected intramuscularly, subcutaneously, or intravenously (in solution) to stimulate cardiovascular activity and respiration and as a means of terminating or attenuating narcosis; it is sometimes used in convulsive therapy for schizophrenia.

References in periodicals archive ?
Piracetam prevents pentylenetetrazol kindling-induced neuronal loss and related learning deficits.
PTZ-induced seizure model: Effects of passionflower on seizure activity induced by subcutaneous injection of 85 mg/kg pentylenetetrazol (PTZ) (Swinyard et al.
The anticonvulsant activity of the extract was further determined after administration of pentylenetetrazol (PTZ).
Pentylenetetrazol was purchased from Sigma, diazepam and naloxone were obtained from Tolidaru Pharmaceuticals (Tehran, Iran), flumazenil was obtained from Roche Pharmaceuticals, and safranal (75% v/v) was purchased from Fluka.
1 ml/10 g, v/w) on chemically induced seizures was investigated by injecting pentylenetetrazol (100 mg/kg, body w.