Pentylenetetrazol


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Related to Pentylenetetrazol: Metrazol

pentylenetetrazol

[¦pent·əl‚ēn′te·trə‚zȯl]
(pharmacology)
C6H10N4 A central nervous system stimulant used as an analeptic.

Pentylenetetrazol

 

or leptazol, a medicinal preparation that exerts a stimulating effect on the central nervous system and stimulates respiration and blood circulation; in large doses it induces convulsions. It is taken internally (in tablets) or injected intramuscularly, subcutaneously, or intravenously (in solution) to stimulate cardiovascular activity and respiration and as a means of terminating or attenuating narcosis; it is sometimes used in convulsive therapy for schizophrenia.

References in periodicals archive ?
PTZ-induced seizure model: Effects of passionflower on seizure activity induced by subcutaneous injection of 85 mg/kg pentylenetetrazol (PTZ) (Swinyard et al.
Pilocarpine (300mg/kg ip), preceded by methylscopolamine (l mg/kg, sc) and pentylenetetrazol (PTZ, 50 mg/kg ip) were used to induce seizures as described previously (Lian et al.
The anticonvulsant activity of the extract was further determined after administration of pentylenetetrazol (PTZ).
Pentylenetetrazol (PTZ), a selective blocker of the chloride channel coupled to the GABAA receptor complex (Sejima et al.
Industrias Quimicas), valproic acid (Abbot Laboratorios do Brasil), baclofen (Biogalenica Quimica e Farmaceutica Ltda--CibaGeigy), diazepam (Roche Produtos Quimicos e Farmaceuticos), phenobarbital (Rhodia Produtos Quimicos e Farmaceuticos), pentylenetetrazol (Sigma Chemical Co.
1991), including protection against pentylenetetrazol (PTZ), picrotoxin and transcorneal electroshock-induced convulsions, hypnotic and hypothermic properties (Elisabetsky et al.