Pentylenetetrazol


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Related to Pentylenetetrazol: Metrazol

pentylenetetrazol

[¦pent·əl‚ēn′te·trə‚zȯl]
(pharmacology)
C6H10N4 A central nervous system stimulant used as an analeptic.

Pentylenetetrazol

 

or leptazol, a medicinal preparation that exerts a stimulating effect on the central nervous system and stimulates respiration and blood circulation; in large doses it induces convulsions. It is taken internally (in tablets) or injected intramuscularly, subcutaneously, or intravenously (in solution) to stimulate cardiovascular activity and respiration and as a means of terminating or attenuating narcosis; it is sometimes used in convulsive therapy for schizophrenia.

References in periodicals archive ?
PTZ-induced seizure model: Effects of passionflower on seizure activity induced by subcutaneous injection of 85 mg/kg pentylenetetrazol (PTZ) (Swinyard et al.
Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method
Pilocarpine (300mg/kg ip), preceded by methylscopolamine (l mg/kg, sc) and pentylenetetrazol (PTZ, 50 mg/kg ip) were used to induce seizures as described previously (Lian et al.
The anticonvulsant activity of the extract was further determined after administration of pentylenetetrazol (PTZ).
Characterization of chemical ingredients and anticonvulsant activity of American skullcap (Scutellaria lateriflora)
Pentylenetetrazol (PTZ), a selective blocker of the chloride channel coupled to the GABAA receptor complex (Sejima et al.
Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems
Industrias Quimicas), valproic acid (Abbot Laboratorios do Brasil), baclofen (Biogalenica Quimica e Farmaceutica Ltda--CibaGeigy), diazepam (Roche Produtos Quimicos e Farmaceuticos), phenobarbital (Rhodia Produtos Quimicos e Farmaceuticos), pentylenetetrazol (Sigma Chemical Co.
Nantenine alkaloid presents anticonvulsant effect on two classical animal models
1991), including protection against pentylenetetrazol (PTZ), picrotoxin and transcorneal electroshock-induced convulsions, hypnotic and hypothermic properties (Elisabetsky et al.
Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils
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