Pentylenetetrazol


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to Pentylenetetrazol: Metrazol

pentylenetetrazol

[¦pent·əl‚ēn′te·trə‚zȯl]
(pharmacology)
C6H10N4 A central nervous system stimulant used as an analeptic.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Pentylenetetrazol

 

or leptazol, a medicinal preparation that exerts a stimulating effect on the central nervous system and stimulates respiration and blood circulation; in large doses it induces convulsions. It is taken internally (in tablets) or injected intramuscularly, subcutaneously, or intravenously (in solution) to stimulate cardiovascular activity and respiration and as a means of terminating or attenuating narcosis; it is sometimes used in convulsive therapy for schizophrenia.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Effect of anandamide on the mean seizure scores induced by pentylenetetrazol (PTZ) -kindling epilepsy in rats.
Electrocorticographical observation of seizures induced by pentylenetetrazol (PTZ) injection in rats.
Animals were injected with pentylenetetrazol (PTZ) (35 mg/kg, ip) on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, 26, 29, 31, and 33 until a specific criterion was met.
Albino rats of either sex of average weight (150-200 g) which were inbred in the central animal house JJM Medical College Davangere, were used to induce convulsions by both electroshock and pentylenetetrazol.
Imipramine hydrochloride (IMI), pentylenetetrazol (PTZ) and the standard compounds for HPLC analysis rutin, hesperidin, quercetin, chrysin, hesperetin, kaempferol and naringin were purchased from Sigma-Aldrich Chemical Co.
Thus, the present study was undertaken to assess the effect of curcumin on pentylenetetrazol (PTZ)-kindling in mice.
Keywords: Passiflora incarnata Passian flower Flavonoid [GABA.sub.A] receptor Epileptic seizure Elevated plus maze Rotarod Pentylenetetrazol
The anticonvulsant activity of American skullcap was determined in rat models of acute seizures induced by pilocarpine and pentylenetetrazol. The results from this study indicate that (1) phenolic compounds, especially flavonoids, are the predominant constituents in American skullcap; (2) American skullcap products have similar constituents, but the content and relative proportions of the individual constituents varies widely; and (3) American skullcap has anticonvulsant activity in rodent models of acute seizures.
Keywords: Cymbopogon winterianus; CNS depressant; Anticonvulsant activity; Pentylenetetrazol; Picrotoxin; Strychnine
stigmas, on seizures induced by pentylenetetrazol. Intracerebroventricular (i.c.v.) microinjection of safranal (4.84, 9.68 and 24.2 [micro]mol) had no effects on tonic and clonic phases as well as mortality upon seizures induced by PTZ (90 mg/kg body wt., i.p.).
Industrias Quimicas), valproic acid (Abbot Laboratorios do Brasil), baclofen (Biogalenica Quimica e Farmaceutica Ltda--CibaGeigy), diazepam (Roche Produtos Quimicos e Farmaceuticos), phenobarbital (Rhodia Produtos Quimicos e Farmaceuticos), pentylenetetrazol (Sigma Chemical Co., USA) and diphenylhydantoin (Sarsa Laboratorio Silva Araujo-Roussel) were used.