Taken together, availability of data, patient performance status
and drug accessibility all appear to play important roles in treatment selection in mRCC.
For example, the Spanish trial only enrolled patients with performance status
0 or 1 .
Improved outcome was also highly correlative with a good performance status
and raised the question whether these patients would have done well with just chemotherapy and radiation alone.
05) for shorter OS were: ECOG performance status
[greater than or equal to]2; symptoms; no prior nephrectomy; microscopic necrosis; number of metastatic sites [greater than or equal to]2; presence of liver, bone, or pancreas metastasis; hemoglobin less than the lower limit of normal (LLN); and serum AKP greater than the upper limit of normal (ULN) among factors at initiation of targeted therapy, as well as the relative dose intensity of the targeting agent in the first month (1M-RDI) of <50%.
Decision Resources' new Emerging Markets Physician & Payer Forum report entitled Emerging Markets Physician & Payer Forum: Payer and Clinician Perspectives on the Role of Premium-Priced Angiogenesis Inhibitors in Brazil and Mexico also finds that--in line with interviewed payer insights--surveyed prescribers of Roche/Genentech/Chugai's Avastin in Brazil and Mexico identify patients with good performance status
as prime candidates for Avastin treatment, along with younger patients and those without comorbidities.
BC patients appeared to have a worse performance status
, with 41% with a ECOG [greater than or equal to]2.
The only risk factors for poor outcome were poor performance status
(defined as ECOG [Eastern Cooperative Oncology Group] performance status
of grade 2 or greater) and a history of arterial thrombotic events.
According to the new report entitled New Therapies Entering the Market May Raise Hurdles: A Malignant Melanoma Study, both ipilimumab and ticilimumab offer clinicians more freedom in treatment design based on the individual patient's performance status
STELLAR 3 is a phase III clinical trial of carboplatin in combination with either XYOTAX or paclitaxel for the potential front-line treatment of poor performance status
(PS2) patients with NSCL cancer.
Response to therapy was evaluated as no change, but the patien t's general condition (Zubrod performance status
score = 1), and the pleural lesion did not change for 21 months.
DISCUS Connect users can login to the server, review workflow notifications and performance status
, and approve requirements about a part or FAI, including the Bill of Documents and Bill of Characteristics.
Conservative treatment was chosen because the fistula tract was suspected to be imperceptible and the patient's performance status
was poor: Eastern Cooperative Oncology Group (ECOG) Performance Status
(PS) grade 4.