Pericyte


Also found in: Medical, Wikipedia.

pericyte

[′per·ə‚sīt]
(histology)
A mesenchymal cell found around a capillary; it may or may not be contractile.

Pericyte

 

(also Rouget cell), a branching cell in the wall of a blood-carrying capillary. The cytoplasm of pericytes is characterized by the presence of fibrillar elements and micropinocytotic vesicles, whose membranes exhibit adenosine triphosphatase activity. The outgrowths of pericytes surround the capillaries and, penetrating the basement membrane, either come into contact with the endothelial cells or are separated from the cells by a narrow space. Some scientists consider pericytes to be partially differentiated cells, capable of being transformed into other cellular elements of connective tissue. Others consider pericytes to be differentiated contractile elements, capable of changing the lumen of the capillary. Still others admit the existence of various types of pericytes, capable of regenerative or contractile functions.

Mentioned in ?
References in periodicals archive ?
Student's t-test was used for comparing the body weight, thermal threshold, MNCV and pericyte density between the two groups.
(ii) Intracellular accumulation of sorbitol leads to osmotic stress in retinal cells including ganglion cells, Muller glia, vascular endothelial cells, and pericytes. (iii) Pathophysiological consequences include thickening of capillary basement membrane, pericyte loss, formation of acellular capillaries, microaneurysms, hemorrhages, glial cell activation, and apoptosis.
Nicanartine, is antihypercholesterolemic which inhibits pericyte loss [153].
Microvascular changes, including thickening of capillary basement membranes, apoptosis of microvascular cells, loss of pericytes, and acellular capillary formation, are major features of DR [2].
Together, these form the perivascular/Virchow-Robin space along with pericytes embedded in the vascular basement membrane that surrounds vascular endothelial cells, which form the BBB in postcapillary venules of the brain.
Li et al., "Hemoglobin induced NO/cGMP suppression deteriorate microcirculation via pericyte phenotype transformation after subarachnoid hemorrhage in rats," Scientific Reports, vol.
PM consists of 500 mL of basal medium, 10 mL of FBS, 5 mL of pericyte growth supplement, and 5 mL of penicillin/streptomycin solution.
Ejaz, "Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy," Diabetes, Obesity & Metabolism, vol.
Secreted by endothelial cells [33], PDGFB plays a critical role in BBB formation and maintenance, acting as a chemoattractant for pericytes [34] and altering gene expression.
Rege et al., "Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain," Nature Neuroscience, vol.
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.
Amputation, as was performed in this case, should be considered a last resort option, as patients with large or multiple AVMs may have reduced wound healing owing to pericyte invasion into vessels and skin.