Student's t-test was used for comparing the body weight, thermal threshold, MNCV and
pericyte density between the two groups.
(ii) Intracellular accumulation of sorbitol leads to osmotic stress in retinal cells including ganglion cells, Muller glia, vascular endothelial cells, and
pericytes. (iii) Pathophysiological consequences include thickening of capillary basement membrane,
pericyte loss, formation of acellular capillaries, microaneurysms, hemorrhages, glial cell activation, and apoptosis.
Nicanartine, is antihypercholesterolemic which inhibits
pericyte loss [153].
Microvascular changes, including thickening of capillary basement membranes, apoptosis of microvascular cells, loss of
pericytes, and acellular capillary formation, are major features of DR [2].
Together, these form the perivascular/Virchow-Robin space along with
pericytes embedded in the vascular basement membrane that surrounds vascular endothelial cells, which form the BBB in postcapillary venules of the brain.
Li et al., "Hemoglobin induced NO/cGMP suppression deteriorate microcirculation via
pericyte phenotype transformation after subarachnoid hemorrhage in rats," Scientific Reports, vol.
PM consists of 500 mL of basal medium, 10 mL of FBS, 5 mL of
pericyte growth supplement, and 5 mL of penicillin/streptomycin solution.
Ejaz, "Importance of
pericytes and mechanisms of
pericyte loss during diabetes retinopathy," Diabetes, Obesity & Metabolism, vol.
Secreted by endothelial cells [33], PDGFB plays a critical role in BBB formation and maintenance, acting as a chemoattractant for
pericytes [34] and altering gene expression.
Rege et al., "
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain," Nature Neuroscience, vol.
Benefits of targeting both
pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.
Amputation, as was performed in this case, should be considered a last resort option, as patients with large or multiple AVMs may have reduced wound healing owing to
pericyte invasion into vessels and skin.