Pericyte

pericyte

[′per·ə‚sīt]

(histology)

A mesenchymal cell found around a capillary; it may or may not be contractile.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Pericyte

(also Rouget cell), a branching cell in the wall of a blood-carrying capillary. The cytoplasm of pericytes is characterized by the presence of fibrillar elements and micropinocytotic vesicles, whose membranes exhibit adenosine triphosphatase activity. The outgrowths of pericytes surround the capillaries and, penetrating the basement membrane, either come into contact with the endothelial cells or are separated from the cells by a narrow space. Some scientists consider pericytes to be partially differentiated cells, capable of being transformed into other cellular elements of connective tissue. Others consider pericytes to be differentiated contractile elements, capable of changing the lumen of the capillary. Still others admit the existence of various types of pericytes, capable of regenerative or contractile functions.

Mentioned in ?

Capillaries

References in periodicals archive ?

Student's t-test was used for comparing the body weight, thermal threshold, MNCV and pericyte density between the two groups.

Pericyte Loss and Detachment in Experimental Cisplatin-Induced Neuropathy/Perdida y Desprendimiento de Pericitos en la Neuropatia Experimental Inducida por Cisplatino

(ii) Intracellular accumulation of sorbitol leads to osmotic stress in retinal cells including ganglion cells, Muller glia, vascular endothelial cells, and pericytes. (iii) Pathophysiological consequences include thickening of capillary basement membrane, pericyte loss, formation of acellular capillaries, microaneurysms, hemorrhages, glial cell activation, and apoptosis.

Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy

Nicanartine, is antihypercholesterolemic which inhibits pericyte loss [153].

Current Advances in Pharmacotherapy and Technology for Diabetic Retinopathy: A Systematic Review

Microvascular changes, including thickening of capillary basement membranes, apoptosis of microvascular cells, loss of pericytes, and acellular capillary formation, are major features of DR [2].

Resveratrol Prevents ROS-Induced Apoptosis in High Glucose-Treated Retinal Capillary Endothelial Cells via the Activation of AMPK/Sirt1/PGC-1a Pathway

Together, these form the perivascular/Virchow-Robin space along with pericytes embedded in the vascular basement membrane that surrounds vascular endothelial cells, which form the BBB in postcapillary venules of the brain.

Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy

Li et al., "Hemoglobin induced NO/cGMP suppression deteriorate microcirculation via pericyte phenotype transformation after subarachnoid hemorrhage in rats," Scientific Reports, vol.

Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke

PM consists of 500 mL of basal medium, 10 mL of FBS, 5 mL of pericyte growth supplement, and 5 mL of penicillin/streptomycin solution.

Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-[kappa]B Pathway

Ejaz, "Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy," Diabetes, Obesity & Metabolism, vol.

Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice

Secreted by endothelial cells [33], PDGFB plays a critical role in BBB formation and maintenance, acting as a chemoattractant for pericytes [34] and altering gene expression.

Gene Expression Changes in Long-Term In Vitro Human Blood-Brain Barrier Models and Their Dependence on a Transwell Scaffold Material

Rege et al., "Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain," Nature Neuroscience, vol.

Seeking a New Paradigm for Alzheimer's Disease: Considering the Roles of Inflammation, Blood-Brain Barrier Dysfunction, and Prion Disease

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.

Dasatinib-induced chylothorax in chronic myeloid leukemia

Amputation, as was performed in this case, should be considered a last resort option, as patients with large or multiple AVMs may have reduced wound healing owing to pericyte invasion into vessels and skin.