Student's t-test was used for comparing the body weight, thermal threshold, MNCV and pericyte
density between the two groups.
(ii) Intracellular accumulation of sorbitol leads to osmotic stress in retinal cells including ganglion cells, Muller glia, vascular endothelial cells, and pericytes
. (iii) Pathophysiological consequences include thickening of capillary basement membrane, pericyte
loss, formation of acellular capillaries, microaneurysms, hemorrhages, glial cell activation, and apoptosis.
Nicanartine, is antihypercholesterolemic which inhibits pericyte
Microvascular changes, including thickening of capillary basement membranes, apoptosis of microvascular cells, loss of pericytes
, and acellular capillary formation, are major features of DR .
Together, these form the perivascular/Virchow-Robin space along with pericytes
embedded in the vascular basement membrane that surrounds vascular endothelial cells, which form the BBB in postcapillary venules of the brain.
Li et al., "Hemoglobin induced NO/cGMP suppression deteriorate microcirculation via pericyte
phenotype transformation after subarachnoid hemorrhage in rats," Scientific Reports, vol.
PM consists of 500 mL of basal medium, 10 mL of FBS, 5 mL of pericyte
growth supplement, and 5 mL of penicillin/streptomycin solution.
Ejaz, "Importance of pericytes
and mechanisms of pericyte
loss during diabetes retinopathy," Diabetes, Obesity & Metabolism, vol.
Secreted by endothelial cells , PDGFB plays a critical role in BBB formation and maintenance, acting as a chemoattractant for pericytes
 and altering gene expression.
Rege et al., "Pericyte
degeneration leads to neurovascular uncoupling and limits oxygen supply to brain," Nature Neuroscience, vol.
Benefits of targeting both pericytes
and endothelial cells in the tumor vasculature with kinase inhibitors.
Amputation, as was performed in this case, should be considered a last resort option, as patients with large or multiple AVMs may have reduced wound healing owing to pericyte
invasion into vessels and skin.