Pericyte

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pericyte

[′per·ə‚sīt]
(histology)
A mesenchymal cell found around a capillary; it may or may not be contractile.

Pericyte

 

(also Rouget cell), a branching cell in the wall of a blood-carrying capillary. The cytoplasm of pericytes is characterized by the presence of fibrillar elements and micropinocytotic vesicles, whose membranes exhibit adenosine triphosphatase activity. The outgrowths of pericytes surround the capillaries and, penetrating the basement membrane, either come into contact with the endothelial cells or are separated from the cells by a narrow space. Some scientists consider pericytes to be partially differentiated cells, capable of being transformed into other cellular elements of connective tissue. Others consider pericytes to be differentiated contractile elements, capable of changing the lumen of the capillary. Still others admit the existence of various types of pericytes, capable of regenerative or contractile functions.

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Morphology of pericytes and the basement membrane shared with endothelial cells was observed with a transmission electron microscope (JEM-1400PLUS; JEOL, Japan).
The team also observed that muscle immobility itself led to a significant decline in the abundance of pericytes in the affected muscle tissues.
Hemangiopericytoma: a vascular tumor featuring zimmermann's pericytes. Ann Surg 1942;116(1):26-33.
SMA-positive pericytes reacted for both endothelial cells and spindle cells in all four reports including the present case which underwent this staining (Table 2).
Others postulate that these cells originated from pericytes, which are essentially progenitors of fat/muscle cells [9,10].
Wakisaka and Nagao first reported the expression of SGLT2 in cultured bovine retinal pericytes [39] highlighting the functional glucose sensor role of SGLT2 in the retinal microvasculature.
Accumulation of sorbitol results in intramural pericytes of retinal capillaries losing their primary function, for example, auto regulation of retinal capillaries [20].
Pericytes are strong contractile cells that form the initial outer layer that gives shape and strength to a developing blood vessel.
The tyrosine kinase platelet-derived growth factor receptor beta (PDGFR-[beta]) on pericytes regulates postnatal angiogenesis, lymphangiogenesis, mesangial and vascular smooth muscle cell proliferation, and pericyte recruitment to capillaries.
A role for pericytes as microenvironmental regulators of human skin tissue regeneration.