Permease


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Related to Permease: transacetylase

permease

[′pər·mē‚ās]
(biochemistry)
Any of a group of enzymes which mediate the phenomenon of active transport.

Permease

 

a component, probably of a protein nature, of certain biological membranes that transports metabolites across the membrane. Each permease transports a specific group of chemically similar compounds, and its biosynthesis is controlled by a single gene. The most extensively studied permeases have been those that transport carbohydrates in bacteria, although permeases for amino acids and several ions are also known. The bacterium Escherichia coli has from 30 to 60 different permeases.

The term “permease” is often extended to imply a functional meaning, that is, to designate an entire multicomponent system for the transport of a certain compound. This usage is erroneous, since permeases cannot be equated with enzymes, which are also named by adding the suffix “-ase.” It has been proposed that permeases be called transport proteins, or transfors.

REFERENCES

De Robertis, E., W. Nowinski, and F. Saez. Biologiia kletki. Moscow, 1973. (Translated from English.)
Cohen, G. N., and J. Monod. “Bacterial Permeases.” Bacteriological Reviews, 1957, vol. 21, no. 3, p. 169.

V. K. ANTONOV

References in periodicals archive ?
Specific detection of Escherichia coli isolated from water samples using polymerase chain reaction targeting four genes: cytochrome bd complex, lactose permease, beta-D-glucuronidase, and beta-D-galactosidase.
2007) TOR-induced resistance to toxic adenosine analogs in Leishmania brought about by the internalization and degradation of the adenosine permease.
Previously determined SNP patterns T/G/T/A or G/T/C/C at Sakai genome positions 337,933 (ECs0320, putative receptor), 1,460,599 (ECs1414, curli production assembly/transport component), 2,370,797 (ECs2397, transport system permease protein), and 5,404,166 (ECs5279, fimH-locus) have been shown to be cluster specific (12).
High levels of intracellular recombinant ANT were able to abrogate the altered trafficking of the NT1 adenosine/thymidine permease elicited by TOR indicating that ANT interacted with TOR.
Board 17 CREATION AND CHARACTERIZATION OF A SILENT EcoRV RESTRICTION SITE IN THE GENE SEQEUNCE OF THE LACTOSE PERMEASE OF ESCHERICHIA COLI BY SITE DIRECTED MUTAGENESIS.
Development of competence in Streptococcus pneumonaie: pheromone autoinduction and control of quorum sensing by the oligopeptide permease.
Truncation mutants showed that the domain responsible for inhibiting permease activity resided at the N terminal portion of TOR.
CP000029), which included an ADP-ribosylglycohydrolase, a permease for cytosine/purines, and a ribokinase (Table 3).
The latter assumption is corroborated by a high similarity of the protein sequence to numerous bacterial permease components of ATP-binding cassette transporters.
Finally, for the purine cytosine permease (FCY2), the sequences of the type strain (GenBank accession no.