peroxynitrite

(redirected from Peroxynitrate)

peroxynitrite

[pə‚räk·sē′nī‚trīt]
(inorganic chemistry)
A nitrogen oxyanion containing an O-O peroxo bond that is a structural isomer of the nitrate ion. Species are generally distinguished by writing the chemical formula for peroxynitrite as ONOO- and nitrate as NO3-. Other names that have been given to peroxynitrite include pernitrite and peroxonitrite; its recommended IUPAC name is oxoperoxonitrate(1-).
References in periodicals archive ?
43,44) Recently research has emerged relating elevated nitrosine, a peroxynitrate marker, as a possible indicator for MCS.
Oxidative stress --the imbalance of pro-oxidant and antioxidant response--has increased radical oxygen species (ROS) production include superoxide anion, hydroxyl radical, hydroxyl peroxide and nitrogen species peroxynitrate.
Nitric oxide produced by NOS combines with superoxide to create peroxynitrate, which is a potent ROS capable of cytotoxic neuronal apoptosis [54, 57].
Microglia are activated by psychosis to release free radicals, also known as reactive oxygen species; these include nitric oxide, superoxide, and peroxynitrate.
A second possible suggestion is that NO rapidly reacts intracellularly to form nitrite and nitrate, S-nitroso-thiols or peroxynitrate, and these metabolites are believed to play key roles in mediating many of the NO-associated genotoxic effects.
Oxidants in cigarette smoke: Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite.
Mechanisms responsible for this secondary damage are not well understood but may involve two toxic molecules produced by injury to the nervous system--nitric oxide and peroxynitrate.
Cocoa acts as substrate for MPO as well as a potent inhibitor of the lipid peroxidation of LDL by MPO or peroxynitrate.
Additionally, NO may combine with superoxide to generate peroxynitrate, a potent destructive pro-oxidant agent in cartilage, which is able to mediate chondrocytes apoptosis (Del Carlo and Loeser 2002; Pacher et al.
Vitamin C is the safest, most powerful and ubiquitous free radical scavenger (antioxidant) known to biology and it can very quickly remove free radicals such as superoxide, nitric oxide, hydroxyl, lipoperoxides and peroxynitrates from organs and tissues.