As will be seen below, peroxynitrite
(ONOO-) is postulated by Martin Pall to be a key player in the MCS exposure mechanism.
Moreover, it can be used to cure sperm motility problem on asthenozoospermic patients, because a critical negative effect of peroxynitrite
(a RNS) on sperm motility was observed when spermatozoa concentration was normal .
Studies in vitro show that green tea catechins effectively scavenge reactive ROS such as superoxide and peroxyl radicals as well as RNS such as nitric oxide and peroxynitrite
Maeda, Helicobacter Pylori Urease Suppresses Bactericidal Activity of Peroxynitrite
Via Carbon Dioxide Production.
It involves various NO-derivatives, such as NO radical, nitroxyl anion (NO-), peroxynitrite
(ONOO-), and S-nitrosothiols (SNOs).
Formation of superoxide and nitric oxide that react together to produce peroxynitrite
, which again exhibits hydroxyl radical-like activity causing hepatotoxicity which is contributed by hepatic macrophages via different mechanisms (Michael et al.
was the main reactive oxygen species found in the whole blood.
5] Moreover, there is an important cross-talk between the tissue NO signaling and XOR, a prototypic superoxide-producing enzyme, as XO-derived superoxide can react with excess NO to form peroxynitrite
, which has adverse effects on tissue homeostasis.
As I consulted with those with chronic Lyme, I noticed that they appeared to have genetic patterns that resulted in the creation of a molecule called peroxynitrite
that is an oxidizing agent that damages the body, adds to the toxic load, depletes glutathione and weakens the immune system.
Other studies show an increase in serum myocardial oxidative markers such as Peroxynitrite
and Superoxide in atrial fibrillation after surgery.
Vascular endothelial cells generate peroxynitrite
in response to carbon monoxide exposure.
Reactive oxygen types formed in vascular system cause decrease in NO concentration (NO combines with superoxide and provides peroxynitrite
to be produced.