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They conclude, "Good evidence of clinical utility must be obtained before pharmacogenomic testing is widely implemented.
An ideal application of pharmacogenomics is to integrate it into clinical and nonclinical studies in order to provide value to pharmaceutical R&D by supplementing the information from these studies," says Sampath.
The database formed from pharmacogenomics research will accommodate the information gathered about a particular gene and the protein it encodes, linking sequence variants in the gene to changes in the structure and function of the encoded protein and the consequences for drug response (Evans & Johnson, 2001; Altman, 2003).
He directs the Interdisciplinary Pharmacogenomics Review Group (IPRG) responsible for the review of genomic data submissions to the FDA.
The subtle distinction between pharmacogenetics and pharmacogenomics has relevance even though both link together genotype with drug response.
Although clinical application of pharmacogenomics may seem daunting, most drugs are metabolized by a relatively small number of pathways.
11 Microarray Technology and Other Methods in Pharmacogenomics Testing
Anyone with an interest in the application of pharmacogenomics in patient care is welcome to join the AACC listserv and can participate in the planned additional services.
The field of pharmacogenomics has been hindered by its inability to determine complex proteomic signatures for prediction and determination of patient responses to treatment," said Dr.
The initial chapters of this report provide an orientation of pharmacogenomics dealmaking and business activities.
Following the Education link at the top of the Tools page takes visitors to a list of other useful resources, including an overview of pharmacogenetics as illustrated usinq the Asthma Case Study and the CYP2D6 Study, and a link to the Minority Pharmacogenomics website.
Applying pharmacogenomics would allow doctors to treat specific segments of the population based on their particular responses to a drug.
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