Finally, as a consequence of the solid-liquid phase transfer catalysis
method, these intermediates reacted with 2- chloroethyl alcohol to prepare the final new products 1-hydroxyethyl-2-substituted phenoxymethyl benzimidazoles (c1-c5) in high yield.
Following an introduction to the topic of process development, chapter topics include chiral technology, strategies to simplify organic reactions and processes, choosing a reagent, phase transfer catalysis
, purity and purification, and safety assessment.
Dehmlow, "Phase transfer catalysis
" Verlag Chemie, Basel 1983.
Jones, In The Quaternary Ammonium Salts Their Use in Phase Transfer Catalysis
, Academic Press, Trowbridge, 2001.
At the present time, the main catalysis systems are gas-liquid phase transfer catalysis
[15, 16], tetrabutylammonium bromide homogeneous catalysis  and NaX zeolite  heterogeneous catalysis.