Phenidone

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Phenidone

the trademark for l-phenyl-3-pyrazolidone, a compound occurring as white, yellowish, or grayish acicular crystals. The structural formula is

Phenidone has a melting point of 121°C (according to other data, 118°–122°C); 1 g of the compound dissolves in 10 cm³ of either boiling water or hot alcohol. Phenidone is soluble in dilute acids and dilute solutions of alkalies, but it is insoluble in benzene. The compound is a strong reducing agent.

Phenidone is obtained through the condensation of phenylhydrazine with β-halopropionic acid. It is used in photography as a developing agent, usually in a mixture with developers.

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Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats.

Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin

Pharmacological inhibition of LOX using dual inhibitors of LOX/COXpathway phenidone [160,166], which decreased the production of CysLTs, or BW755C [167] attenuated the seizure activity.

Shin et al., "Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity," Neuroscience Letters, vol.

Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases

Phenidone, a well-known 5-LOX inhibitor used as a positive control in theses assays, had an [IC.sub.50] of 1.3 [micro]g/mL.

Flavocoxid, a nutraceutical approach to blunt inflammatory conditions

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