Phenidone

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Phenidone

 

the trademark for l-phenyl-3-pyrazolidone, a compound occurring as white, yellowish, or grayish acicular crystals. The structural formula is

Phenidone has a melting point of 121°C (according to other data, 118°–122°C); 1 g of the compound dissolves in 10 cm3 of either boiling water or hot alcohol. Phenidone is soluble in dilute acids and dilute solutions of alkalies, but it is insoluble in benzene. The compound is a strong reducing agent.

Phenidone is obtained through the condensation of phenylhydrazine with β-halopropionic acid. It is used in photography as a developing agent, usually in a mixture with developers.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats.
Pharmacological inhibition of LOX using dual inhibitors of LOX/COXpathway phenidone [160,166], which decreased the production of CysLTs, or BW755C [167] attenuated the seizure activity.
Shin et al., "Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity," Neuroscience Letters, vol.
Phenidone, a well-known 5-LOX inhibitor used as a positive control in theses assays, had an [IC.sub.50] of 1.3 [micro]g/mL.