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C12H12N2O3 A crystalline compound, 5-ethyl-5-phenylbarbituric acid, with a slightly bitter taste, melting at 174-178°C; soluble in water, alcohol, chloroform, and ether; used in medicine as a long-acting sedative, anticonvulsant, and hypnotic.



(trade name, Luminal), a medicinal preparation of the barbiturate group. Taken in powder or tablet form, phenobarbital is a long-acting soporific and is used in the treatment of such conditions as epilepsy and vascular spasms. Phenobarbital may be combined, in tablet form, with various other substances, including analgesic and spasmolytic preparations (for example, Andipal, Camphodal, or Paluphin).

References in periodicals archive ?
34) This parrot continued with generalized seizures, despite treatment with phenobarbital and potassium bromide.
5, 25, 50, 100 and 200 mg/kg or 40 mg/kg dose of phenobarbital or 10 ml/kg normal saline were injected to different groups of mice and 20 min after the injection, 12 mg/kg dose of picrotoxin were administered to in addition to the anticonvulsant effect of FU, the most effective dose is determined.
Switch to Librium (chlor-diazepoxide) or phenobarbital in an outpatient setting at a time when patients are physiologically improved.
Although phenobarbital is very long acting, there seemed to me to be practical reasons to administer the phenobarbital in three doses per day, one dose on each nursing shift.
All anti-epileptic drugs used in monotherapy were associated with a significantly increased risk of fracture except for valproic acid, phenobarbital and "other anti-epileptic drugs.
Electronystagmography (ENG) was performed while the patient remained on the phenytoin and phenobarbital.
Three were taking Phenobarbital, one in association with lamotrigine and the last took lamotrigine with valproic acid.
To date, the patient has remained seizure-free for six months on phenobarbital monotherapy.
Though the DEN and phenobarbital has close relationship with free radical production during hepatocarcinogenesis our present studies in male rats of Wistar albino rats established the protective role of apigenin on DEN induced and phenobarbital promoted hepatocellular carcinogenesis.
The bioethicist indicated the principle of "double effect" could justify giving high doses of phenobarbital in an attempt to attain improved seizure control.
Rats were anesthetized with phenobarbital (50 mg/kg, intraperitoneal).
Examples of barbiturates are: Amytal, Florinal, Nembutal, Tuinal, Seconal, and Phenobarbital.